Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration

Onderzoeksoutputpeer review

55 Citaten (Scopus)


This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.

Originele taal-2English
Pagina's (van-tot)44-57
Aantal pagina's14
TijdschriftBritish Journal of Anaesthesia
Nummer van het tijdschrift1
StatusPublished - 2017

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