Phosphate and FGF-23 homeostasis after kidney transplantation

Leandro C. Baia, Ita Pfeferman Heilberg, Gerjan Navis*, Martin H. de Borst, NIGRAM Investigators

*Corresponding author voor dit werk

Onderzoeksoutputpeer review

56 Citaten (Scopus)

Samenvatting

Dysregulated phosphate metabolism is a common consequence of chronic kidney disease, and is characterized by a high circulating level of fibroblast growth factor (FGF)-23, hyperparathyroidism, and hyperphosphataemia. Kidney transplantation can elicit specific alterations to phosphate metabolism that evolve over time, ranging from severe hypophosphataemia (1.50 mmol/l) and high FGF-23 levels. The majority of renal transplant recipients develop hypophosphataemia during the first 3 months after transplantation as a consequence of relatively slow adaptation of FGF-23 and parathyroid hormone levels to restored renal function, and the influence of immunosuppressive drugs. By 3-12 months after transplantation, phosphate homeostasis is at least partially restored in the majority of recipients, which is paralleled by a substantially reduced risk of cardiovascular-associated morbidity and mortality compared with the pre-transplantation setting. Many renal transplant recipients, however, exhibit persistent abnormalities in phosphate homeostasis, which is often due to multifactorial causes, and may contribute to adverse outcomes on the cardiovascular system, kidney, and bone. Dietary and pharmacologic interventions might improve phosphate homeostasis in renal transplant recipients, but additional insight into the pathophysiology of transplantation-associated abnormalities in phosphate homeostasis is needed to further optimize disease management and improve prognosis for renal transplant recipients.

Originele taal-2English
Pagina's (van-tot)656-666
Aantal pagina's11
TijdschriftNature Reviews Nephrology
Volume11
Nummer van het tijdschrift11
DOI's
StatusPublished - nov.-2015

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