Photo-induced processes within noncovalent complexes involved in molecular recognition

M. Abdelmouleh, Mathieu Lalande, Violaine Vizcaino, Thomas Schlathölter, Jean-Christophe Poully*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

7 Citaten (Scopus)
69 Downloads (Pure)

Samenvatting

Investigating the intrinsic properties of molecular complexes is crucial for understanding the influence of noncovalent interactions on fundamental chemical reactions. Moreover, specific molecular recognition between a ligand and its receptor is a highly important biological process, but little is known about the effects of ionizing radiation on ligand–receptor complexes. The processes triggered by VUV photoabsorption on isolated noncovalent complexes between the glycopeptide antibiotic vancomycin and a mimic of its receptor have been probed by means of mass spectrometry and synchrotron radiation. In the case of protonated species, the glycosidic bond of vancomycin was cleaved with low activation energy, regardless of the molecular environment. In sharp contrast, for deprotonated species, electron photodetachment from carboxylate groups only triggered CO2 loss, whereas the glycosidic bond remained intact. Importantly, the noncovalent complex was also found to survive VUV photoabsorption only when the native structure is conserved in the gas phase.

Originele taal-2English
Pagina's (van-tot) 2243-2250
Aantal pagina's8
TijdschriftChemistry - A European Journal
Volume26
Nummer van het tijdschrift10
Vroegere onlinedatum2-dec.-2019
DOI's
StatusPublished - 20-feb.-2020

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