Photocaging of Carboxylic Acids: A Modular Approach

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21 Citaten (Scopus)

Samenvatting

Photocaged compounds are important tools for studying and regulating multiple processes, including biological functions. Reported herein is the use of the Passerini multicomponent reaction for modular preparation of photocaged carboxylic acids. The reaction is compatible with several functionalities and proceeds smoothly both in water and dichloromethane. The choice of aldehyde determines the wavelength used for deprotection and enables formation of orthogonally protected products. The isocyanide component can be used for introduction of reactive tags and photosensitizers, as well as for immobilization on a solid support.

Originele taal-2English
Pagina's (van-tot)8682-8686
Aantal pagina's5
TijdschriftAngewandte Chemie - International Edition
Volume53
Nummer van het tijdschrift33
DOI's
StatusPublished - 11-aug-2014

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