Photopharmacology: Beyond Proof of Principle

Willem A. Velema, Wiktor Szymanski*, Bernard Feringa

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

669 Citaten (Scopus)
1794 Downloads (Pure)

Samenvatting

Pharmacotherapy is often severely hindered by issues related to poor drug selectivity, including side effects, environmental toxicity, and the emergence of resistance. Lack of selectivity is caused by the inability to control drug activity in time and space. Photopharmacology aims at solving this issue by incorporating photoswitchable groups into the molecular structure of bioactive compounds. These switching units allow for the use of light as an external control element for pharmacological activity, which can be delivered with very high spatiotemporal precision. This Perspective presents the reader with the current state and outlook on photopharmacology. In particular, the principles behind photoregulation of bioactivity, the challenges of molecular design, and the possible therapeutic scenarios are discussed.

Originele taal-2English
Pagina's (van-tot)2178-2191
Aantal pagina's14
TijdschriftJournal of the American Chemical Society
Volume136
Nummer van het tijdschrift6
DOI's
StatusPublished - 2014

Citeer dit