Physical virology: From virus self-assembly to particle mechanics

Pedro Buzón*, Sourav Maity, Wouter H Roos

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

29 Citaten (Scopus)
170 Downloads (Pure)


Viruses are highly ordered supramolecular complexes that have evolved to propagate by hijacking the host cell's machinery. Although viruses are very diverse, spreading through cells of all kingdoms of life, they share common functions and properties. Next to the general interest in virology, fundamental viral mechanisms are of growing importance in other disciplines such as biomedicine and (bio)nanotechnology. However, in order to optimally make use of viruses and virus-like particles, for instance as vehicle for targeted drug delivery or as building blocks in electronics, it is essential to understand their basic chemical and physical properties and characteristics. In this context, the number of studies addressing the mechanisms governing viral properties and processes has recently grown drastically. This review summarizes a specific part of these scientific achievements, particularly addressing physical virology approaches aimed to understand the self-assembly of viruses and the mechanical properties of viral particles. Using a physicochemical perspective, we have focused on fundamental studies providing an overview of the molecular basis governing these key aspects of viral systems. This article is categorized under: Biology-Inspired Nanomaterials > Protein and Virus-Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

Originele taal-2English
Aantal pagina's22
TijdschriftWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Nummer van het tijdschrift4
Vroegere onlinedatum20-jan.-2020
StatusPublished - jul.-2020

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