Pinpointing Functionally Relevant miRNAs in Classical Hodgkin Lymphoma Pathogenesis

Yujia Pan, Roza Cengiz, Joost Kluiver, Arjan Diepstra, Anke Van den Berg*

*Corresponding author voor dit werk

Onderzoeksoutputpeer review

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Samenvatting

Classical Hodgkin lymphoma (cHL) is a hematological malignancy of B-cell origin. The tumor cells in cHL are referred to as Hodgkin and Reed-Sternberg (HRS) cells. This review provides an overview of the currently known miRNA-target gene interactions. In addition, we pinpointed other potential regulatory roles of microRNAs (miRNAs) by focusing on genes related to processes relevant for cHL pathogenesis, i.e., loss of B-cell phenotypes, immune evasion, and growth support. A cHL-specific miRNA signature was generated based on the available profiling studies. The interactions relevant for cHL were extracted by comprehensively reviewing the existing studies on validated miRNA-target gene interactions. The miRNAs with potential critical roles included miR-155-5p, miR-148a-3p, miR-181a-5p, miR-200, miR-23a-3p, miR-125a/b, miR-130a-3p, miR-138, and miR-143-3p, which target, amongst others, PU.1, ETS1, HLA-I, PD-L1, and NF-κB component genes. Overall, we provide a comprehensive perspective on the relevant miRNA-target gene interactions which can also serve as a foundation for future functional studies into the specific roles of the selected miRNAs in cHL pathogenesis.

Originele taal-2English
Artikelnummer1126
Aantal pagina's17
TijdschriftCancers
Volume16
Nummer van het tijdschrift6
DOI's
StatusPublished - 12-mrt.-2024

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