Plasma Procalcitonin Is Associated with Obesity, Insulin Resistance, and the Metabolic Syndrome

Ali Abbasi; Eva Corpeleijn; Douwe Postmus; Ron T. Gansevoort; Paul E. de Jong; Rijk O. B. Gans; Joachim Struck; Hans L. Hillege; Ronald P. Stolk; Gerjan Navis; Stephan J. L. Bakker

doi:10.1210/jc.2010-0305

Plasma Procalcitonin Is Associated with Obesity, Insulin Resistance, and the Metabolic Syndrome

Ali Abbasi^*, Eva Corpeleijn, Douwe Postmus, Ron T. Gansevoort, Paul E. de Jong, Rijk O. B. Gans, Joachim Struck, Hans L. Hillege, Ronald P. Stolk, Gerjan Navis, Stephan J. L. Bakker

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Article › Academic › peer review

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Context: Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation.

Objectives: The objective of this study was to investigate whether plasma procalcitonin levels in the normal range are associated with obesity, insulin resistance, and metabolic syndrome (MS) in the general population.

Methods: Plasma procalcitonin (0.006-0.1 ng/ml) was measured in 3197 men and 3638 women (aged 28-75 yr) of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study using an ultra-sensitive immunoluminometric assay. MS was defined according to Adult Treatment Panel III criteria.

Results: Median (interquartile range) plasma procalcitonin was 0.018 (0.015-0.022) ng/ml in men and0.014 (0.012-0.017) ng/ml inwomen(P

Conclusions: Elevated plasma procalcitonin levels in the normal range are associated with measures of obesity, insulin resistance, and MS in the general population. (J Clin Endocrinol Metab 95: E26-E31, 2010)

Originele taal-2	English
Pagina's (van-tot)	E26-E31
Aantal pagina's	6
Tijdschrift	Journal of Clinical Endocrinology & Metabolism
Volume	95
Nummer van het tijdschrift	9
DOI's	https://doi.org/10.1210/jc.2010-0305
Status	Published - sep.-2010

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Prevention of Renal and Vascular End-stage Disease (PREVEND)
Gansevoort, R. (Creator), University of Groningen, 2017
https://www.umcg.nl/EN/Research/Researchers/Facilities/biobanks/biobanks/prevend/Paginas/default.aspx#
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title = "Plasma Procalcitonin Is Associated with Obesity, Insulin Resistance, and the Metabolic Syndrome",

abstract = "Context: Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation.Objectives: The objective of this study was to investigate whether plasma procalcitonin levels in the normal range are associated with obesity, insulin resistance, and metabolic syndrome (MS) in the general population.Methods: Plasma procalcitonin (0.006-0.1 ng/ml) was measured in 3197 men and 3638 women (aged 28-75 yr) of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study using an ultra-sensitive immunoluminometric assay. MS was defined according to Adult Treatment Panel III criteria.Results: Median (interquartile range) plasma procalcitonin was 0.018 (0.015-0.022) ng/ml in men and0.014 (0.012-0.017) ng/ml inwomen(PConclusions: Elevated plasma procalcitonin levels in the normal range are associated with measures of obesity, insulin resistance, and MS in the general population. (J Clin Endocrinol Metab 95: E26-E31, 2010)",

keywords = "GENE-RELATED PEPTIDE, HUMAN ADIPOSE-TISSUE, CALCITONIN-GENE, INFLAMMATION, EXPRESSION, INFECTION, SEPSIS",

author = "Ali Abbasi and Eva Corpeleijn and Douwe Postmus and Gansevoort, {Ron T.} and {de Jong}, {Paul E.} and Gans, {Rijk O. B.} and Joachim Struck and Hillege, {Hans L.} and Stolk, {Ronald P.} and Gerjan Navis and Bakker, {Stephan J. L.}",

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T1 - Plasma Procalcitonin Is Associated with Obesity, Insulin Resistance, and the Metabolic Syndrome

AU - Abbasi, Ali

AU - Corpeleijn, Eva

AU - Postmus, Douwe

AU - Gansevoort, Ron T.

AU - de Jong, Paul E.

AU - Gans, Rijk O. B.

AU - Struck, Joachim

AU - Hillege, Hans L.

AU - Stolk, Ronald P.

AU - Navis, Gerjan

AU - Bakker, Stephan J. L.

N1 - Article

PY - 2010/9

Y1 - 2010/9

N2 - Context: Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation.Objectives: The objective of this study was to investigate whether plasma procalcitonin levels in the normal range are associated with obesity, insulin resistance, and metabolic syndrome (MS) in the general population.Methods: Plasma procalcitonin (0.006-0.1 ng/ml) was measured in 3197 men and 3638 women (aged 28-75 yr) of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study using an ultra-sensitive immunoluminometric assay. MS was defined according to Adult Treatment Panel III criteria.Results: Median (interquartile range) plasma procalcitonin was 0.018 (0.015-0.022) ng/ml in men and0.014 (0.012-0.017) ng/ml inwomen(PConclusions: Elevated plasma procalcitonin levels in the normal range are associated with measures of obesity, insulin resistance, and MS in the general population. (J Clin Endocrinol Metab 95: E26-E31, 2010)

AB - Context: Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation.Objectives: The objective of this study was to investigate whether plasma procalcitonin levels in the normal range are associated with obesity, insulin resistance, and metabolic syndrome (MS) in the general population.Methods: Plasma procalcitonin (0.006-0.1 ng/ml) was measured in 3197 men and 3638 women (aged 28-75 yr) of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study using an ultra-sensitive immunoluminometric assay. MS was defined according to Adult Treatment Panel III criteria.Results: Median (interquartile range) plasma procalcitonin was 0.018 (0.015-0.022) ng/ml in men and0.014 (0.012-0.017) ng/ml inwomen(PConclusions: Elevated plasma procalcitonin levels in the normal range are associated with measures of obesity, insulin resistance, and MS in the general population. (J Clin Endocrinol Metab 95: E26-E31, 2010)

KW - GENE-RELATED PEPTIDE

KW - HUMAN ADIPOSE-TISSUE

KW - CALCITONIN-GENE

KW - INFLAMMATION

KW - EXPRESSION

KW - INFECTION

KW - SEPSIS

U2 - 10.1210/jc.2010-0305

DO - 10.1210/jc.2010-0305

M3 - Article

SN - 0021-972X

VL - 95

SP - E26-E31

JO - Journal of Clinical Endocrinology & Metabolism

JF - Journal of Clinical Endocrinology & Metabolism

IS - 9

ER -

Plasma Procalcitonin Is Associated with Obesity, Insulin Resistance, and the Metabolic Syndrome

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Prevention of Renal and Vascular End-stage Disease (PREVEND)

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