Plasticity of the adult human small intestinal stoma microbiota

Bahtiyar Yilmaz*, Tobias Fuhrer, Deborah Morgenthaler, Niklas Krupka, Daoming Wang, Daniel Spari, Daniel Candinas, Benjamin Misselwitz, Guido Beldi, Uwe Sauer, Andrew J. Macpherson*

*Corresponding author voor dit werk

    OnderzoeksoutputAcademicpeer review

    22 Citaten (Scopus)
    178 Downloads (Pure)

    Samenvatting

    The human distal small intestine (ileum) has a distinct microbiota, but human studies investigating its composition and function have been limited by the inaccessibility of the ileum without purging and/or deep intubation. We investigated inherent instability, temporal dynamics, and the contribution of fed and fasted states using stoma samples from cured colorectal cancer patients as a non-invasive access route to the otherwise inaccessible small and large intestines. Sequential sampling of the ileum before and after stoma formation indicated that ileostoma microbiotas represented that of the intact small intestine. Ileal and colonic stoma microbiotas were confirmed as distinct, and two types of instability in ileal host-microbial relationships were observed: inter-digestive purging followed by the rapid postprandial blooming of bacterial biomass and sub-strain appearance and disappearance within individual taxa after feeding. In contrast to the relative stability of colonic microbiota, the human small intestinal microbiota biomass and its sub-strain composition can be highly dynamic.

    Originele taal-2English
    Pagina's (van-tot)1773-1787
    Aantal pagina's22
    TijdschriftCell Host and Microbe
    Volume30
    Nummer van het tijdschrift12
    Vroegere onlinedatum31-okt.-2022
    DOI's
    StatusPublished - 14-dec.-2022

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