Samenvatting
The enzymatic hydrolyses of a variety of alpha-substituted mandelic and lactic esters using pig liver esterase (PLE) have been investigated. High to moderate enantioselectivity was found for various alpha-substituted mandelic esters, whereas PLE showed low to no enantioselectivity for alpha-substituted lactic esters. We observed that the enantioselectivity of PLE depends strongly on the length and nature of the substituent at the alpha-position. Some consequences for an active site model of PLE are discussed.
| Originele taal-2 | English |
|---|---|
| Pagina's (van-tot) | 705-720 |
| Aantal pagina's | 16 |
| Tijdschrift | Tetrahedron-Asymmetry |
| Volume | 2 |
| Nummer van het tijdschrift | 7 |
| Status | Published - 1991 |