Pneumococcal conjugate vaccines overcome splenic dependency of antibody response to pneumococcal polysaccharides

MA Breukels*, A Zandvoort, GPJM van den Dobbelsteen, A van den Muijsenberg, ME Lodewijk, M Beurret, PA Klok, W Timens, GT Rijkers

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

49 Citaten (Scopus)

Samenvatting

Protection against infectious with Streptococcus pneumoniae depends on the presence of antibodies against capsular polysaccharides that facilitate phagocytosis. Asplenic patients are at increased risk for pneumococcal infections, since both phagocytosis and the initiation of the antibody response to polysaccharides take place in the spleen. Therefore, vaccination with pneumococcal polysaccharide vaccines is recommended prior to splenectomy, which, as in the case of trauma, is not always feasible. We show that in rats, vaccination with a pneumococcal conjugate vaccine can induce good antibody responses even after splenectomy, particularly after a second dose. The spleen remains necessary for a fast, primary response to (blood-borne) polysaccharides, even when they are presented in a conjugated form. Coadministration of a conjugate vaccine with additional nonconjugated polysaccharides of other serotypes did not improve the response to the nonconjugated polysaccharides. We conclude that pneumococcal conjugate vaccines can be of value in protecting asplenic or hyposplenic patients against pneumococcal infections.

Originele taal-2English
Pagina's (van-tot)7583-7587
Aantal pagina's5
TijdschriftInfection and Immunity
Volume69
Nummer van het tijdschrift12
StatusPublished - dec.-2001

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