Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow

Gabriela Imbir*, Aldona Mzyk, Klaudia Trembecka-Wójciga, Ewa Jasek-Gajda, Hanna Plutecka, Romana Schirhagl, Roman Major

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    5 Citaten (Scopus)
    59 Downloads (Pure)

    Samenvatting

    Surface functionalization of materials to improve their hemocompatibility is a challenging problem in the field of blood-contacting devices and implants. Polyelectrolyte multilayer films (PEMs), which can mimic functions and structure of an extracellular matrix (ECM), are a promising solution to the urgent need for functional blood-contacting coatings. The properties of PEMs can be easily tuned in order to provide a scaffold with desired physico-chemical parameters. In this study chitosan/chondroitin sulfate (Chi/CS) polyelectrolyte multilayers were deposited on medical polyurethane. Afterwards PEMs were modified by chemical cross-linking and nanoparticles introduction. Coatings with variable properties were tested for their hemocompatibility in the cone-plate tester under dynamic conditions. The obtained results enable the understanding of how substrate properties modulate PEMs interaction with blood plasma proteins and the morphotic elements.

    Originele taal-2English
    Artikelnummer859
    Aantal pagina's17
    TijdschriftNanomaterials (Basel, Switzerland)
    Volume10
    Nummer van het tijdschrift5
    DOI's
    StatusPublished - mei-2020

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