Polymeric peptide pigments with sequence-encoded properties

Ayala Lampel, Scott A. McPhee, Hang-Ah Park, Gary K. Scott, Sunita Humagain, Doeke R. Hekstra, Barney Yoo, Pim W. J. M. Frederix, Tai-De Li, Rinat R. Abzalimov, Steven G. Greenbaum, Tell Tuttle, Chunhua Hu, Christopher J. Bettinger, Rein V. Ulijn*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

197 Citaten (Scopus)
336 Downloads (Pure)

Samenvatting

Melanins are a family of heterogeneous polymeric pigments that provide ultraviolet (UV) light protection, structural support, coloration, and free radical scavenging. Formed by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are influenced by covalent and noncovalent disorder. We report the use of tyrosine-containing tripeptides as tunable precursors for polymeric pigments. In these structures, phenols are presented in a (supra-)molecular context dictated by the positions of the amino acids in the peptide sequence. Oxidative polymerization can be tuned in a sequence-dependent manner, resulting in peptide sequence-encoded properties such as UV absorbance, morphology, coloration, and electrochemical properties over a considerable range. Short peptides have low barriers to application and can be easily scaled, suggesting near-term applications in cosmetics and biomedicine.

Originele taal-2English
Pagina's (van-tot)1064-1068
Aantal pagina's5
TijdschriftScience
Volume356
Nummer van het tijdschrift6342
DOI's
StatusPublished - 9-jun.-2017
  • CCDC 1539905: Experimental Crystal Structure Determination

    Lampel, A. (Contributor), McPhee, S. A. (Contributor), Park, H. (Contributor), Scott, G. G. (Contributor), Humagain, S. (Contributor), Hekstra, D. R. (Contributor), Yoo, B. (Contributor), Frederix, P. (Contributor), Li, T. (Contributor), Abzalimov, R. R. (Contributor), Greenbaum, S. G. (Contributor), Tuttle, T. (Contributor), Hu, C. (Contributor), Bettinger, C. J. (Contributor) & Ulijn, R. V. (Contributor), University of Groningen, 23-mrt.-2017

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