Population-level analysis of gut microbiome variation

Gwen Falony, Marie Joossens, Sara Vieira-Silva, Jun Wang, Youssef Darzi, Karoline Faust, Aleksandr Kurilshchikov, Marc Jan Bonder, Mireia Valles-Colomer, Doris Vandeputte, Raul Y. Tito, Samuel Chaffron, Leen Rymenans, Chlo Verspecht, Lise De Sutter, Gipsi Lima-Mendez, Kevin D'hoe, Karl Jonckheere, Daniel Homola, Roberto GarciaEttje F. Tigchelaar, Linda Eeckhaudt, Jingyuan Fu, Liesbet Henckaerts, Alexandra Zhernakova, Cisca Wijmenga, Jeroen Raes*

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

1506 Citaten (Scopus)

Samenvatting

Fecal microbiome variation in the average, healthy population has remained under-investigated. Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian Flemish Gut Flora Project (FGFP; discovery cohort; N = 1106) and the Dutch LifeLines-DEEP study (LLDeep; replication; N = 1135). Integration with global data sets (N combined = 3948) revealed a 14-genera core microbiota, but the 664 identified genera still underexplore total gut diversity. Sixty-nine clinical and questionnaire-based covariates were found associated to microbiota compositional variation with a 92% replication rate. Stool consistency showed the largest effect size, whereas medication explained largest total variance and interacted with other covariate-microbiota associations. Early-life events such as birth mode were not reflected in adult microbiota composition. Finally, we found that proposed disease marker genera associated to host covariates, urging inclusion of the latter in study design.

Originele taal-2English
Pagina's (van-tot)560-564
Aantal pagina's5
TijdschriftScience
Volume352
Nummer van het tijdschrift6285
DOI's
StatusPublished - 29-apr.-2016

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