PREPARATION, CHARACTERIZATION AND PHARMACEUTICAL APPLICATION OF LINEAR DEXTRINS .4. DRUG-RELEASE FROM CAPSULES AND TABLETS CONTAINING AMYLODEXTRIN

GHPT WIERIK, AC EISSENS, CF LERK

OnderzoeksoutputAcademicpeer review

7 Citaten (Scopus)

Samenvatting

Linear dextrin (amylodextrin) and its soluble fraction were investigated for their suitability to enhance diazepam release from capsules and tablets. Drug release was analyzed in the USP XXI paddle apparatus and performed in phosphate buffer pH 6.8, with and without alpha-amylase, and in 0.1 N HCl solution. Diazepam release from capsules was slightly increased on application of amylodextrin, either as a filler in a physical mixture or as a carrier for solid dispersion of the drug, as compared to the release from capsules containing drug only. The limited increase in drug dissolution is caused by the limited solubility of amylodextrin. Application of the soluble fraction of amylodextrin therefore showed faster drug release. In contrast, the limited solubility and non-disintegrating behaviour of amylodextrin appeared to be extremely suitable properties to apply this excipient in the formulation of programmed release systems.

Originele taal-2English
Pagina's (van-tot)219-224
Aantal pagina's6
TijdschriftInternational Journal of Pharmaceutics
Volume98
Nummer van het tijdschrift1-3
StatusPublished - 31-aug-1993

Citeer dit