Presence and Predictive Value of Obsessive-Compulsive Symptoms in Anxiety and Depressive Disorders

Mieke Klein Hofmeijer-Sevink*, Neeltje M. Batelaan, Harold J. G. M. van Megen, Marcel A. van den Hout, Brenda W. Penninx, Anton J. L. M. van Balkom, Danielle C. Cath

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    14 Citaten (Scopus)
    289 Downloads (Pure)


    Objective: Obsessive-compulsive symptoms (OCS) co-occur frequently with anxiety and depressive disorders, but the nature of their relationship and their impact on severity of anxiety and depressive disorders is poorly understood. In a large sample of patients with anxiety and depressive disorders, we assessed the frequency of OCS, defined as a Young Adult Self-Report Scale-obsessive-compulsive symptoms score >7. The associations between OCS and severity of anxiety and/or depressive disorders were examined, and it was investigated whether OCS predict onset, relapse, and persistence of anxiety and depressive disorders.

    Methods: Data were obtained from the third (at 2-year follow-up) and fourth wave (at 4-year follow-up) of data collection in the Netherlands Study of Anxiety and Depression cohort, including 469 healthy controls, 909 participants with a remitted disorder, and 747 participants with a current anxiety and/or depressive disorder.

    Results: OCS were present in 23.6% of the total sample, most notably in those with current combined anxiety and depressive disorders. In patients with a current disorder, OCS were associated with severity of this disorder. Moreover, OCS predicted (1) first onset of anxiety and/or depressive disorders in healthy controls (odds ratio [OR], 5.79; 95% confidence interval [CI], 1.15 to 29.14), (2) relapse in those with remitted anxiety and/or depressive disorders (OR, 2.31; 95% CI, 1.55 to 3.46), and (3) persistence in patients with the combination of current anxiety and depressive disorders (OR, 4.42; 95% CI, 2.54 to 7.70) within the 2-year follow-up period

    Conclusions: OCS are closely related to both the presence and severity of anxiety and depressive disorders and affect their course trajectories. Hence, OCS might be regarded as a course specifier signaling unfavorable outcomes. This specifier may be useful in clinical care to adapt and intensify treatment in individual patients.

    Originele taal-2English
    Pagina's (van-tot)85-93
    Aantal pagina's9
    TijdschriftThe Canadian Journal of Psychiatry
    Nummer van het tijdschrift2
    StatusPublished - 2018

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