TY - JOUR
T1 - Prevalence and characteristics of noncompliant behaviour and its risk factors in kidney transplant recipients
AU - Rosenberger, J.
AU - Geckova, A.M.
AU - van Dijk, J.P.
AU - Nagyova, I.
AU - Roland, R.
AU - van den Heuvel, W.J.
AU - Groothoff, J.W.
PY - 2005/9
Y1 - 2005/9
N2 - Noncompliance with therapy is one possible explanation for the observation that long-term graft survival is not sufficiently improved by the development in immunosuppression. The aim of the study was to explore the prevalence, characteristics and risk factors of noncompliance with immunosuppression. A total of 161 adult kidney transplant recipients were inter-viewed about their self-rated health, social support, education, stress from adverse effects and compliance with the immunosuppression. The prevalence of subclinical noncompliance was 54%. Noncompliant patients declared significantly worse self-rated health, less satisfaction with social support and higher stress from adverse effects. Male gender (OR 7.5, CI 2.4-23.39), high stress from adverse effects (OR 12.27, CI 2.44-61.88), fair self-rated health (OR 4.45, CI 1.04-19.55) and fair satisfaction with social support (OR 4.55, CI 1.08-19.24) were predictors of noncompliance. Standardized detection methods should be developed with the aim of identifying patients who are at risk of noncompliance in order to prevent graft loss.
AB - Noncompliance with therapy is one possible explanation for the observation that long-term graft survival is not sufficiently improved by the development in immunosuppression. The aim of the study was to explore the prevalence, characteristics and risk factors of noncompliance with immunosuppression. A total of 161 adult kidney transplant recipients were inter-viewed about their self-rated health, social support, education, stress from adverse effects and compliance with the immunosuppression. The prevalence of subclinical noncompliance was 54%. Noncompliant patients declared significantly worse self-rated health, less satisfaction with social support and higher stress from adverse effects. Male gender (OR 7.5, CI 2.4-23.39), high stress from adverse effects (OR 12.27, CI 2.44-61.88), fair self-rated health (OR 4.45, CI 1.04-19.55) and fair satisfaction with social support (OR 4.55, CI 1.08-19.24) were predictors of noncompliance. Standardized detection methods should be developed with the aim of identifying patients who are at risk of noncompliance in order to prevent graft loss.
KW - adverse effects
KW - compliance immunosuppression
KW - self-rated health
KW - transplantation
KW - QUALITY-OF-LIFE
KW - LATE ACUTE REJECTION
KW - RENAL-TRANSPLANT
KW - IMMUNOSUPPRESSIVE THERAPY
KW - MEDICATION NONCOMPLIANCE
KW - ORGAN TRANSPLANT
KW - PATIENT
KW - DETERMINANTS
KW - MULTICENTER
KW - EXPERIENCE
U2 - 10.1111/j.1432-2277.2005.00183.x
DO - 10.1111/j.1432-2277.2005.00183.x
M3 - Article
SN - 1432-2277
VL - 18
SP - 1072
EP - 1078
JO - Transplant International
JF - Transplant International
IS - 9
ER -