prM-antibody renders immature West Nile virus infectious in vivo

Tonya M. Colpitts, Izabela Rodenhuis-Zybert, Bastiaan Moesker, Penghua Wang, Erol Fikrig, Jolanda M. Smit*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

29 Citaten (Scopus)

Samenvatting

West Nile virus (WNV) is a member of the family Flaviviridae and is a neurotropic pathogen responsible for severe human disease. Flavivirus-infected cells release virus particles that contain variable numbers of precursor membrane (prM) protein molecules at the viral surface. Consequently, antibodies are produced against the prM protein. These antibodies have been shown to activate the infectious potential of fully immature flavivirus particles in vitro. Here, we provide in vivo proof that prM antibodies render immature WNV infectious. Infection with antibody-opsonized immature WNV particles caused disease and death of mice, and infectious WNV was found in the brains and sera.

Originele taal-2English
Pagina's (van-tot)2281-2285
Aantal pagina's5
TijdschriftJournal of general virology
Volume92
DOI's
StatusPublished - okt-2011

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