Prognostic value of HMGN family expression in acute myeloid leukemia

Wei Cui, Yuna Liu, Yanan Tan, Xingyue Peng, Longzhen Cui, Zhiheng Cheng, Yifeng Dai, Lin Fu, Tiansheng Zeng, Yan Liu

    OnderzoeksoutputAcademicpeer review

    3 Citaten (Scopus)
    82 Downloads (Pure)

    Samenvatting

    Aim: The objective of this work was to investigate the prognostic role of the HMGN family in acute myeloid leukemia (AML). Methods: A total of 155 AML patients with HMGN1-5 expression data from the Cancer Genome Atlas database were enrolled in this study. Results: In the chemotherapy-only group, patients with high HMGN2 expression had significantly longer event-free survival (EFS) and overall survival (OS) than those with low expression (all p < 0.05), whereas high HMGN5 expressers had shorter EFS and OS than the low expressers (all p < 0.05). Multivariate analysis identified that high HMGN2 expression was an independent favorable prognostic factor for patients who only received chemotherapy (all p < 0.05). HMGN family expression had no impact on EFS and OS in AML patients receiving allogeneic hematopoietic stem cell transplantation. Conclusion: High HMGN2/5 expression is a potential prognostic indicator for AML.

    Originele taal-2English
    Pagina's (van-tot)541-548
    Aantal pagina's8
    TijdschriftFuture oncology
    Volume17
    Nummer van het tijdschrift5
    Vroegere onlinedatum20-jan.-2021
    DOI's
    StatusPublished - feb.-2021

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