Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

Yoav P Talmi; Robert P Takes; Eran E Alon; Iain J Nixon; Fernando López; Remco de Bree; Juan P Rodrigo; Ashok R Shaha; Gyorgy B Halmos; Alessandra Rinaldo; Alfio Ferlito

doi:10.1002/hed.25080

Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

Yoav P Talmi, Robert P Takes, Eran E Alon, Iain J Nixon, Fernando López, Remco de Bree, Juan P Rodrigo, Ashok R Shaha, Gyorgy B Halmos, Alessandra Rinaldo, Alfio Ferlito

Onderzoeksoutput › peer review

43 Citaten (Scopus)

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BACKGROUND: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC).

METHODS: A PubMed internet search was performed and articles meeting selection criteria were reviewed.

RESULTS: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09.

CONCLUSION: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.

Originele taal-2	English
Pagina's (van-tot)	1082-1090
Aantal pagina's	9
Tijdschrift	Head and Neck: Journal of the Sciences and Specialties of the Head and Neck
Volume	40
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1002/hed.25080
Status	Published - 2018

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Prognostic value of lymph node ratio in head and neck squamous cell carcinoma
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title = "Prognostic value of lymph node ratio in head and neck squamous cell carcinoma",

abstract = "BACKGROUND: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC).METHODS: A PubMed internet search was performed and articles meeting selection criteria were reviewed.RESULTS: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09.CONCLUSION: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.",

keywords = "NUMBER, VALIDATION, ORAL-CAVITY CANCER, AMERICAN JOINT COMMITTEE, HYPOPHARYNGEAL CANCER, ADJUVANT THERAPY, SURVIVAL, PREDICTOR, DENSITY, METASTASES",

author = "Talmi, {Yoav P} and Takes, {Robert P} and Alon, {Eran E} and Nixon, {Iain J} and Fernando L{\'o}pez and {de Bree}, Remco and Rodrigo, {Juan P} and Shaha, {Ashok R} and Halmos, {Gyorgy B} and Alessandra Rinaldo and Alfio Ferlito",

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year = "2018",

doi = "10.1002/hed.25080",

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pages = "1082--1090",

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TY - JOUR

T1 - Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

AU - Talmi, Yoav P

AU - Takes, Robert P

AU - Alon, Eran E

AU - Nixon, Iain J

AU - López, Fernando

AU - de Bree, Remco

AU - Rodrigo, Juan P

AU - Shaha, Ashok R

AU - Halmos, Gyorgy B

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC).METHODS: A PubMed internet search was performed and articles meeting selection criteria were reviewed.RESULTS: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09.CONCLUSION: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.

AB - BACKGROUND: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC).METHODS: A PubMed internet search was performed and articles meeting selection criteria were reviewed.RESULTS: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09.CONCLUSION: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.

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KW - VALIDATION

KW - ORAL-CAVITY CANCER

KW - AMERICAN JOINT COMMITTEE

KW - HYPOPHARYNGEAL CANCER

KW - ADJUVANT THERAPY

KW - SURVIVAL

KW - PREDICTOR

KW - DENSITY

KW - METASTASES

U2 - 10.1002/hed.25080

DO - 10.1002/hed.25080

M3 - Review article

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SN - 1043-3074

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SP - 1082

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JO - Head and Neck: Journal of the Sciences and Specialties of the Head and Neck

JF - Head and Neck: Journal of the Sciences and Specialties of the Head and Neck

IS - 5

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Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

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