Prognostic Value of MicroRNA-20b in Acute Myeloid Leukemia

Zhiheng Cheng, Yifeng Dai, Wenhui Huang, Qingfu Zhong, Pei Zhu, Wenjuan Zhang, Zhihua Wu, Qing Lin, Huoyan Zhu, Longzhen Cui, Tingting Qian, Cong Deng, Lin Fu, Yan Liu, Tiansheng Zeng*

*Corresponding author voor dit werk

    OnderzoeksoutputAcademicpeer review

    6 Citaten (Scopus)
    64 Downloads (Pure)

    Samenvatting

    Acute myeloid leukemia (AML) is a highly heterogeneous disease that requires fine-grained risk stratification for the best prognosis of patients. As a class of small non-coding RNAs with important biological functions, microRNAs play a crucial role in the pathogenesis of AML. To assess the prognostic impact of miR-20b on AML in the presence of other clinical and molecular factors, we screened 90 AML patients receiving chemotherapy only and 74 also undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) from the Cancer Genome Atlas (TCGA) database. In the chemotherapy-only group, high miR-20b expression subgroup had shorter event-free survival (EFS) and overall survival (OS, both P < 0.001); whereas, there were no significant differences in EFS and OS between high and low expression subgroups in the allo-HSCT group. Then we divided all patients into high and low expression groups based on median miR-20b expression level. In the high expression group, patients treated with allo-HSCT had longer EFS and OS than those with chemotherapy alone (both P < 0.01); however, there were no significant differences in EFS and OS between different treatment subgroups in the low expression group. Further analysis showed that miR-20b was negatively correlated with genes in "ribosome," "myeloid leukocyte mediated immunity," and "DNA replication" signaling pathways. ORAI2, the gene with the strongest correlation with miR-20b, also had significant prognostic value in patients undergoing chemotherapy but not in the allo-HSCT group. In conclusion, our findings suggest that high miR-20b expression is a poor prognostic indicator for AML, but allo-HSCT may override its prognostic impact.

    Originele taal-2English
    Artikelnummer553344
    Aantal pagina's9
    TijdschriftFrontiers in Oncology
    Volume10
    DOI's
    StatusPublished - 18-feb.-2021

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