Prognostic value of the PDLIM family in acute myeloid leukemia

Longzhen Cui, Zhiheng Cheng, Kai Hu, Yifan Pang, Yan Liu, Tingting Qian, Liang Quan, Yifeng Dai, Ying Pang, Xu Ye, Jinlong Shi, Lin Fu*

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

12 Citaten (Scopus)

Samenvatting

Acute myeloid leukemia (AML) is a genetically complex, highly aggressive hematological malignancy. Prognosis is usually with grim. PDZ and LIM domain proteins (PDLIM) are involved in the regulation of a variety of biological processes, including cytoskeletal organization, cell differentiation, organ development, neural signaling or tumorigenesis. The clinical and prognostic value of the PDLIM family in AML is unclear. To understand the role of PDLIM expression in AML, The Cancer Genome Atlas (TCGA) database was screened and 155 de novo AML patients with complete clinical information and the expression data of the PDLIM family were included in the study. The clinical and molecular characteristics associated with the expression of different members of the PDLIM family were summarized using various statistical methods. In 84 patients who only received chemotherapy, univariate analysis indicated that high expression of PDLIM2 or PDLIM7 was associated with shorter EFS and OS (both P

Originele taal-2English
Pagina's (van-tot)6124-6131
Aantal pagina's8
TijdschriftAmerican journal of translational research
Volume11
Nummer van het tijdschrift9
StatusPublished - 2019

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