Putting a Hold on the Downward Spiral of Paranoia in the Social World: A Randomized Controlled Trial of Mindfulness-Based Cognitive Therapy in Individuals with a History of Depression

Dina Collip*, Nicole Geschwind, Frenk Peeters, Inez Myin-Germeys, Jim van Os, Marieke Wichers

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

20 Citaten (Scopus)
15 Downloads (Pure)


Context: Paranoia embodies altered representation of the social environment, fuelling altered feelings of social acceptance leading to further mistrust. Mindfulness-based cognitive therapy (MBCT) may relieve paranoia and reduce its impact on social acceptance.

Objective: To determine whether MBCT alters momentary feeling of paranoia and social acceptance in daily life.

Design: Randomized controlled trial of daily-life repeated measures (up to 120 per participant) before and after allocation to MBCT or waiting list control.

Participants: Volunteer sample of 130 eligible men and women with residual affective dysregulation after at least one episode of major depressive disorder.

Interventions: Eight weeks of MBCT in groups of 10-15 participants in addition to participants' usual treatment.

Outcome Measures: Daily-life ratings of paranoia and social acceptance. This manuscript concerns additional analyses of the original trial; hypotheses were developed after data collection (focus initially on depressive symptoms) but before data analysis.

Results: Sixty-six participants were assigned to the waiting list control group and 64 to the MBCT intervention group, of whom 66 and 61 respectively were included in the per-protocol analyses. Intention-to-treat analyses revealed a significant group by time interaction in the model of momentary paranoia (b = -.18, p

Conclusions: MBCT confers a substantial benefit on subclinical paranoia and may interrupt the social processes that maintain and foster paranoia in individuals with residual affective dysregulation.

Originele taal-2English
Aantal pagina's7
TijdschriftPLoS ONE
Nummer van het tijdschrift6
StatusPublished - 27-jun-2013
Extern gepubliceerdJa

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