Quantification, improvement, and harmonization of small lesion detection with state-of-the-art PET

Charlotte S. van der Vos, Danielle Koopman, Sjoerd Rijnsdorp, Albert J. Arends, Ronald Boellaard, Jorn A. van Dalen, Mark Lubberink, Antoon T. M. Willemsen, Eric P. Visser*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articleAcademicpeer review

93 Citaten (Scopus)
1185 Downloads (Pure)


In recent years, there have been multiple advances in positron emission tomography/computed tomography (PET/CT) that improve cancer imaging. The present generation of PET/CT scanners introduces new hardware, software, and acquisition methods. This review describes these new developments, which include time-of-flight (TOF), point-spread-function (PSF), maximum-a-posteriori (MAP) based reconstruction, smaller voxels, respiratory gating, metal artefact reduction, and administration of quadratic weight-dependent F-18-fluorodeoxyglucose (FDG) activity. Also, hardware developments such as continuous bed motion (CBM), (digital) solid-state photodetectors and combined PET and magnetic resonance (MR) systems are explained. These novel techniques have a significant impact on cancer imaging, as they result in better image quality, improved small lesion detectability, and more accurate quantification of radiopharmaceutical uptake. This influences cancer diagnosis and staging, as well as therapy response monitoring and radiotherapy planning. Finally, the possible impact of these developments on the European Association of Nuclear Medicine (EANM) guidelines and EANM Research Ltd. (EARL) accreditation for FDG-PET/CT tumor imaging is discussed.

Originele taal-2English
Pagina's (van-tot)S4-S16
Aantal pagina's13
TijdschriftEuropean Journal of Nuclear Medicine and Molecular Imaging
StatusPublished - aug-2017

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