Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI

Super-FRS Experiment Collaboration, Daria Boscolo, Daria Kostyleva, Mohammad Javad Safari, Vasiliki Anagnostatou, Juha Äystö, Soumya Bagchi, Tim Binder, Georgios Dedes, Peter Dendooven, Timo Dickel, Vasyl Drozd, Bernhard Franczack, Hans Geissel, Chiara Gianoli, Christian Graeff, Tuomas Grahn, Florian Greiner, Emma Haettner, Roghieh HaghaniMuhsin N. Harakeh, Felix Horst, Christine Hornung, Jan-Paul Hucka, Nasser Kalantar-Nayestanaki, Erika Kazantseva, Birgit Kindler, Ronja Knöbel, Natalia Kuzminchuk-Feuerstein, Bettina Lommel, Ivan Mukha, Chiara Nociforo, Shunki Ishikawa, Giulio Lovatti, Munetaka Nitta, Ikechi Ozoemelam, Stephane Pietri, Wolfgang R. Plass, Andrej Prochazka, Sivaji Purushothaman, Claire-Anne Reidel, Heidi Roesch, Fabio Schirru, Christoph Schuy, Olga Sokol, Timo Steinsberger, Yoshiki K. Tanaka, Isao Tanihata, Peter Thirolf, Walter Tinganelli, Bernd Voss, Uli Weber, Helmut Weick, John S. Winfield, Martin Winkler, Jianwei Zhao, Christoph Scheidenberger, Katia Parodi, Marco Durante*

*Bijbehorende auteur voor dit werk

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Samenvatting

Several techniques are under development for image-guidance in particle therapy. Positron (beta(+)) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by beta(+)-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using beta(+)-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

Originele taal-2English
Artikelnummer737050
Aantal pagina's15
TijdschriftFrontiers in Oncology
Volume11
DOI's
StatusPublished - 19-aug-2021

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