This editorial summarizes the papers published in issue 15(2) so as to raise the bar in applied spatial economic research and highlight new trends. The first paper combines a conditionally autoregressive process from the spatial statistics literature with a spatial Durbin error model from the spatial econometrics literature. The second paper feeds a multistage and multilevel data envelopment analysis with a microeconomic foundation. The third paper provides empirical evidence that Flegg's location quotient combined with a gravity model produces the most accurate interregional input-output multipliers. The fourth paper investigates the impact of inventor networks on the number of patents per capita in Brazil.