Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications

Janine Jansen; Mark J. Boerakker; Jean Heuts; Jan Feijen; Dirk W. Grijpma

doi:10.1016/j.jconrel.2010.06.031

Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications

Janine Jansen
, Mark J. Boerakker
, Jean Heuts
, Jan Feijen
, Dirk W. Grijpma^*

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

36 Citaten (Scopus)

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Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NW and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release. (C) 2010 Elsevier B.V. All rights reserved.

Originele taal-2	English
Pagina's (van-tot)	54-61
Aantal pagina's	8
Tijdschrift	Journal of Controlled Release
Volume	147
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.jconrel.2010.06.031
Status	Published - 1-okt.-2010

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@article{af54d147cbaa4d4b942c994935b421f4,

title = "Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications",

abstract = "Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NW and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release. (C) 2010 Elsevier B.V. All rights reserved.",

keywords = "Biodegradable polymer networks, Poly(trimethylene carbonate), Fumaric acid monoethyl ester, N-vinyl-2-pyrrolidone, Vinyl acetate, Photo-crosslinking kinetics, IN-VITRO DEGRADATION, TRIMETHYLENE CARBONATE, BIODEGRADABLE NETWORKS, EPSILON-CAPROLACTONE, CONTROLLED-RELEASE, POLYMERS, BEHAVIOR, INSTABILITY, COPOLYMERS, ANHYDRIDE",

author = "Janine Jansen and Boerakker, \{Mark J.\} and Jean Heuts and Jan Feijen and Grijpma, \{Dirk W.\}",

year = "2010",

month = oct,

day = "1",

doi = "10.1016/j.jconrel.2010.06.031",

language = "English",

volume = "147",

pages = "54--61",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier Bedrijfsinformatie b.v.",

number = "1",

}

TY - JOUR

T1 - Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications

AU - Jansen, Janine

AU - Boerakker, Mark J.

AU - Heuts, Jean

AU - Feijen, Jan

AU - Grijpma, Dirk W.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NW and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release. (C) 2010 Elsevier B.V. All rights reserved.

AB - Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NW and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release. (C) 2010 Elsevier B.V. All rights reserved.

KW - Biodegradable polymer networks

KW - Poly(trimethylene carbonate)

KW - Fumaric acid monoethyl ester

KW - N-vinyl-2-pyrrolidone

KW - Vinyl acetate

KW - Photo-crosslinking kinetics

KW - IN-VITRO DEGRADATION

KW - TRIMETHYLENE CARBONATE

KW - BIODEGRADABLE NETWORKS

KW - EPSILON-CAPROLACTONE

KW - CONTROLLED-RELEASE

KW - POLYMERS

KW - BEHAVIOR

KW - INSTABILITY

KW - COPOLYMERS

KW - ANHYDRIDE

U2 - 10.1016/j.jconrel.2010.06.031

DO - 10.1016/j.jconrel.2010.06.031

M3 - Article

SN - 0168-3659

VL - 147

SP - 54

EP - 61

JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 1

ER -

Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications

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