Reasons for switching between antipsychotics in daily clinical practice

GWK Hugenholtz, ER Heerdink*, WE Meijer, JJ Stolker, ACG Egberts, WA Nolen

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

34 Citaten (Scopus)

Samenvatting

Background: Previous research that atypical antipsychotics were switched less often compared to typical antipsychotics, suggesting overall better treatment satisfaction. The objective of this study was to investigate the reasons for switching antipsychotics after initiating oral treatment with either typical or atypical antipsychotics in a clinical setting. Patients and Methods: A total of 123 patients that switched antipsychotic therapy were recruited from 17 psychiatric hospitals, of which 46 % switched because of lack of effect and 45 % because of adverse effects. Results: No significant differences were found between users of atypical versus typical antipsychotics in reasons for switching, both for overall adverse events, and lack of effect. In users of atypical antipsychotics extrapyramidal effects were reported less often as reason for switching (adjusted OR = 0.18 (95 % Cl = (0.07-0.51)). Patients on atypical antipsychotics switched more often because of weight gain (adjusted OR = 12.8 (95 % Cl = (1.50-109)). Conclusion: in conclusion, when switching occurred, no difference was found in the frequency of general tolerability or reported lack of effectiveness. However, the type of adverse event as a reason for switching differed between atypical and typical antipsychotics.

Originele taal-2English
Pagina's (van-tot)122-124
Aantal pagina's3
TijdschriftPharmacopsychiatry
Volume38
Nummer van het tijdschrift3
DOI's
StatusPublished - mei-2005

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