TY - JOUR
T1 - Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System
AU - Ye, Huan
AU - Zhou, Yang
AU - Liu, Xun
AU - Chen, Yongbing
AU - Duan, Shanzhou
AU - Zhu, Rongying
AU - Liu, Yong
AU - Yin, Lichen
PY - 2019/7
Y1 - 2019/7
N2 - Reactive oxygen species (ROS) play crucial roles in biological metabolism and intercellular signaling. However, ROS level is dramatically elevated due to abnormal metabolism during multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. By taking advantage of the discrepancy of ROS levels between normal and diseased tissues, a variety of ROS-sensitive moieties or linkers have been developed to design ROS-responsive systems for the site-specific delivery of drugs and genes. In this review, we summarized the ROS-responsive chemical structures, mechanisms, and delivery systems, focusing on their current advances for precise drug/ gene delivery. In particular, ROS-responsive nanocarriers, prodrugs, and supramolecular hydrogels are summarized in terms of their application for drug/gene delivery, and common strategies to elevate or diminish cellular ROS concentrations, as well as the recent development of ROS-related imaging probes were also discussed.
AB - Reactive oxygen species (ROS) play crucial roles in biological metabolism and intercellular signaling. However, ROS level is dramatically elevated due to abnormal metabolism during multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. By taking advantage of the discrepancy of ROS levels between normal and diseased tissues, a variety of ROS-sensitive moieties or linkers have been developed to design ROS-responsive systems for the site-specific delivery of drugs and genes. In this review, we summarized the ROS-responsive chemical structures, mechanisms, and delivery systems, focusing on their current advances for precise drug/ gene delivery. In particular, ROS-responsive nanocarriers, prodrugs, and supramolecular hydrogels are summarized in terms of their application for drug/gene delivery, and common strategies to elevate or diminish cellular ROS concentrations, as well as the recent development of ROS-related imaging probes were also discussed.
KW - TELLURIUM-CONTAINING POLYMER
KW - AMPHIPHILIC BLOCK-COPOLYMERS
KW - RING-OPENING POLYMERIZATION
KW - TUMOR OXIDATIVE STRESS
KW - HYDROGEN-PEROXIDE
KW - INTRACELLULAR DELIVERY
KW - SINGLET-OXYGEN
KW - CROSS-LINKING
KW - DRUG-RELEASE
KW - TRIGGERED DEGRADATION
U2 - 10.1021/acs.biomac.9b00628
DO - 10.1021/acs.biomac.9b00628
M3 - Review article
SN - 1525-7797
VL - 20
SP - 2441
EP - 2463
JO - Biomacromolecules
JF - Biomacromolecules
IS - 7
ER -