@article{70373c879a27485cbc9f3fddd34b5d71,
title = "Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds",
abstract = "Carbon-nitrogen (C−N) lyases are enzymes that normally catalyze the cleavage of C−N bonds. Reversing this reaction towards carbon-nitrogen bond formation can be a powerful approach to prepare valuable compounds that could find applications in everyday life. This review focuses on recent (last five years) applications of native and engineered C−N lyases, either as stand-alone biocatalysts or as part of multienzymatic and chemoenzymatic cascades, in enantioselective synthesis of noncanonical amino acids and dinitrogen-fused heterocycles, which are useful tools for neurobiological research and important synthetic precursors to pharmaceuticals and food additives.",
keywords = "PHENYLALANINE AMMONIA-LYASE, 3-SUBSTITUTED ASPARTIC ACIDS, DIAMINE-DISUCCINIC ACID, CHEMOENZYMATIC SYNTHESIS, KINETIC RESOLUTION, INHIBITOR, ENZYME, EDDS, ASPERGILLOMARASMINE, ETHYLENEDIAMINE",
author = "Jielin Zhang and Abidin, {Mohammad Z.} and Thangavelu Saravanan and Poelarends, {Gerrit J.}",
note = "Funding Information: We acknowledge financial support from the Netherlands Organization of Scientific Research (VICI grant 724.016.002) and from the European Research Council (PoC grant 713483). J.Z. acknowledges funding from the China Scholarship Council, and M.Z.A. acknowledges funding from the Indonesia Endowment Fund for Education (LPDP). Publisher Copyright: {\textcopyright} 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA",
year = "2020",
month = oct,
day = "1",
doi = "10.1002/cbic.202000214",
language = "English",
volume = "21",
pages = "2733--2742",
journal = "ChemBioChem",
issn = "1439-4227",
publisher = "WILEY-V C H VERLAG GMBH",
number = "19",
}