Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds

Jielin Zhang, Mohammad Z. Abidin, Thangavelu Saravanan, Gerrit J. Poelarends*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

5 Citaten (Scopus)
125 Downloads (Pure)

Samenvatting

Carbon-nitrogen (C−N) lyases are enzymes that normally catalyze the cleavage of C−N bonds. Reversing this reaction towards carbon-nitrogen bond formation can be a powerful approach to prepare valuable compounds that could find applications in everyday life. This review focuses on recent (last five years) applications of native and engineered C−N lyases, either as stand-alone biocatalysts or as part of multienzymatic and chemoenzymatic cascades, in enantioselective synthesis of noncanonical amino acids and dinitrogen-fused heterocycles, which are useful tools for neurobiological research and important synthetic precursors to pharmaceuticals and food additives.

Originele taal-2English
Pagina's (van-tot)2733-2742
Aantal pagina's10
TijdschriftChemBioChem
Volume21
Nummer van het tijdschrift19
Vroegere onlinedatum21-apr.-2020
DOI's
StatusPublished - 1-okt.-2020

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