Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health

Lara Marise Wierenga; Amber Ruigrok; Eira Ranheim Aksnes; Claudia Barth; Dani Beck; Sarah Burke; Arielle Crestol; Lina van Drunen; Maria Ferrara; Liisa Ann Margaret Galea; Anne-Lise Goddings; Markus Hausmann; Inka Homanen; Ineke Klinge; Ann-Marie de Lange; Lieke Ouwerkerk; Anna van der Miesen; Ricarda Proppert; Carlotta Rieble; Christian Krog Tamnes; Marieke Geerte Nynke Bos

doi:10.1016/j.bpsgos.2023.100283

Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health

Lara Marise Wierenga^*, Amber Ruigrok, Eira Ranheim Aksnes, Claudia Barth, Dani Beck, Sarah Burke, Arielle Crestol, Lina van Drunen, Maria Ferrara, Liisa Ann Margaret Galea, Anne-Lise Goddings, Markus Hausmann, Inka Homanen, Ineke Klinge, Ann-Marie de Lange, Lieke Ouwerkerk, Anna van der Miesen, Ricarda Proppert, Carlotta Rieble, Christian Krog TamnesMarieke Geerte Nynke Bos

^*Corresponding author voor dit werk

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There are prominent sex/gender differences in the prevalence, expression, and life span course of mental health and neurodiverse conditions. However, the underlying sex- and gender-related mechanisms and their interactions are still not fully understood. This lack of knowledge has harmful consequences for those with mental health problems. Therefore, we set up a cocreation session in a 1-week workshop with a multidisciplinary team of 25 researchers, clinicians, and policy makers to identify the main barriers in sex and gender research in the neuroscience of mental health. Based on this work, here we provide recommendations for methodologies, translational research, and stakeholder involvement. These include guidelines for recording, reporting, analysis beyond binary groups, and open science. Improved understanding of sex- and gender-related mechanisms in neuroscience may benefit public health because this is an important step toward precision medicine and may function as an archetype for studying diversity.

Originele taal-2	English
Artikelnummer	100283
Aantal pagina's	9
Tijdschrift	Biological Psychiatry Global Open Science
Volume	4
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1016/j.bpsgos.2023.100283
Status	Published - mrt.-2024

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Wierenga, L. M., Ruigrok, A., Aksnes, E. R., Barth, C., Beck, D., Burke, S., Crestol, A., van Drunen, L., Ferrara, M., Galea, L. A. M., Goddings, A.-L., Hausmann, M., Homanen, I., Klinge, I., de Lange, A.-M., Ouwerkerk, L., van der Miesen, A., Proppert, R., Rieble, C., ... Bos, M. G. N. (2024). Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health. Biological Psychiatry Global Open Science, 4(2), Artikel 100283. https://doi.org/10.1016/j.bpsgos.2023.100283

@article{e8c96b9c73fe4671af6d0b70fa1f397b,

title = "Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health",

abstract = "There are prominent sex/gender differences in the prevalence, expression, and life span course of mental health and neurodiverse conditions. However, the underlying sex- and gender-related mechanisms and their interactions are still not fully understood. This lack of knowledge has harmful consequences for those with mental health problems. Therefore, we set up a cocreation session in a 1-week workshop with a multidisciplinary team of 25 researchers, clinicians, and policy makers to identify the main barriers in sex and gender research in the neuroscience of mental health. Based on this work, here we provide recommendations for methodologies, translational research, and stakeholder involvement. These include guidelines for recording, reporting, analysis beyond binary groups, and open science. Improved understanding of sex- and gender-related mechanisms in neuroscience may benefit public health because this is an important step toward precision medicine and may function as an archetype for studying diversity.",

keywords = "Brain, Gender, Mental health, Sex, Neurodiverse conditions",

author = "Wierenga, {Lara Marise} and Amber Ruigrok and Aksnes, {Eira Ranheim} and Claudia Barth and Dani Beck and Sarah Burke and Arielle Crestol and {van Drunen}, Lina and Maria Ferrara and Galea, {Liisa Ann Margaret} and Anne-Lise Goddings and Markus Hausmann and Inka Homanen and Ineke Klinge and {de Lange}, Ann-Marie and Lieke Ouwerkerk and {van der Miesen}, Anna and Ricarda Proppert and Carlotta Rieble and Tamnes, {Christian Krog} and Bos, {Marieke Geerte Nynke}",

note = "Crown Copyright {\textcopyright} 2023 Published by Elsevier Inc on behalf of Society of Biological Psychiatry.",

year = "2024",

month = mar,

doi = "10.1016/j.bpsgos.2023.100283",

language = "English",

volume = "4",

journal = "Biological Psychiatry Global Open Science",

issn = "2667-1743",

publisher = "Elsevier",

number = "2",

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Wierenga, LM, Ruigrok, A, Aksnes, ER, Barth, C, Beck, D, Burke, S, Crestol, A, van Drunen, L, Ferrara, M, Galea, LAM, Goddings, A-L, Hausmann, M, Homanen, I, Klinge, I, de Lange, A-M, Ouwerkerk, L, van der Miesen, A, Proppert, R, Rieble, C, Tamnes, CK & Bos, MGN 2024, 'Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health', Biological Psychiatry Global Open Science, vol. 4, nr. 2, 100283. https://doi.org/10.1016/j.bpsgos.2023.100283

TY - JOUR

T1 - Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health

AU - Wierenga, Lara Marise

AU - Ruigrok, Amber

AU - Aksnes, Eira Ranheim

AU - Barth, Claudia

AU - Beck, Dani

AU - Burke, Sarah

AU - Crestol, Arielle

AU - van Drunen, Lina

AU - Ferrara, Maria

AU - Galea, Liisa Ann Margaret

AU - Goddings, Anne-Lise

AU - Hausmann, Markus

AU - Homanen, Inka

AU - Klinge, Ineke

AU - de Lange, Ann-Marie

AU - Ouwerkerk, Lieke

AU - van der Miesen, Anna

AU - Proppert, Ricarda

AU - Rieble, Carlotta

AU - Tamnes, Christian Krog

AU - Bos, Marieke Geerte Nynke

PY - 2024/3

Y1 - 2024/3

N2 - There are prominent sex/gender differences in the prevalence, expression, and life span course of mental health and neurodiverse conditions. However, the underlying sex- and gender-related mechanisms and their interactions are still not fully understood. This lack of knowledge has harmful consequences for those with mental health problems. Therefore, we set up a cocreation session in a 1-week workshop with a multidisciplinary team of 25 researchers, clinicians, and policy makers to identify the main barriers in sex and gender research in the neuroscience of mental health. Based on this work, here we provide recommendations for methodologies, translational research, and stakeholder involvement. These include guidelines for recording, reporting, analysis beyond binary groups, and open science. Improved understanding of sex- and gender-related mechanisms in neuroscience may benefit public health because this is an important step toward precision medicine and may function as an archetype for studying diversity.

AB - There are prominent sex/gender differences in the prevalence, expression, and life span course of mental health and neurodiverse conditions. However, the underlying sex- and gender-related mechanisms and their interactions are still not fully understood. This lack of knowledge has harmful consequences for those with mental health problems. Therefore, we set up a cocreation session in a 1-week workshop with a multidisciplinary team of 25 researchers, clinicians, and policy makers to identify the main barriers in sex and gender research in the neuroscience of mental health. Based on this work, here we provide recommendations for methodologies, translational research, and stakeholder involvement. These include guidelines for recording, reporting, analysis beyond binary groups, and open science. Improved understanding of sex- and gender-related mechanisms in neuroscience may benefit public health because this is an important step toward precision medicine and may function as an archetype for studying diversity.

KW - Brain

KW - Gender

KW - Mental health

KW - Sex

KW - Neurodiverse conditions

U2 - 10.1016/j.bpsgos.2023.100283

DO - 10.1016/j.bpsgos.2023.100283

M3 - Review article

C2 - 38312851

SN - 2667-1743

VL - 4

JO - Biological Psychiatry Global Open Science

JF - Biological Psychiatry Global Open Science

IS - 2

M1 - 100283

ER -

Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health

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