Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm

Kaja Sitkowska; Martijn F. Hoes; Michael M. Lerch; Lucien N. Lameijer; Peter van der Meer; Wiktor Szymanski; Ben L. Feringa

doi:10.1039/d0cc02178d

Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm

Kaja Sitkowska, Martijn F. Hoes, Michael M. Lerch, Lucien N. Lameijer, Peter van der Meer, Wiktor Szymanski^*, Ben L. Feringa^*

^*Corresponding author voor dit werk

Onderzoeksoutput: Article › Academic › peer review

68 Citaten (Scopus)

165 Downloads (Pure)

Samenvatting

Control of biological function by the use of photoremovable protecting groups (PPGs) is a gateway towards many new medical developments. Herein, we report the synthesis and application of efficient and biocompatible BODIPY-based photoprotecting groups for amines, which are cleavable with red light in the phototherapeutic window region (λ > 650 nm). We use the most promising PPG for the protection of dopamine and apply it to control the beating frequency of human cardiomyocytes.

Originele taal-2	English
Pagina's (van-tot)	5480-5483
Aantal pagina's	4
Tijdschrift	Chemical Communications
Volume	56
Nummer van het tijdschrift	41
DOI's	https://doi.org/10.1039/d0cc02178d
Status	Published - 21-mei-2020

Toegang tot document

10.1039/d0cc02178dLicentie: CC BY-NC

Red-light-sensitive BODIPY photoprotectinggroups for amines and their biological applicationin controlling heart rhythmFinal publisher's version, 2,45 MBLicentie: CC BY-NC

Handle.net

Permanente koppeling

Citeer dit

@article{a22430da58234b2e99db8b57951db3a5,

title = "Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm",

abstract = "Control of biological function by the use of photoremovable protecting groups (PPGs) is a gateway towards many new medical developments. Herein, we report the synthesis and application of efficient and biocompatible BODIPY-based photoprotecting groups for amines, which are cleavable with red light in the phototherapeutic window region (λ > 650 nm). We use the most promising PPG for the protection of dopamine and apply it to control the beating frequency of human cardiomyocytes.",

keywords = "PHOTOREMOVABLE PROTECTING GROUPS, PHOTOACTIVATABLE PRODRUGS, REACTION-MECHANISMS, OPTICAL CONTROL, CROSS-SECTIONS, WAVELENGTH, REACTIVITY, DOPAMINE, RELEASE",

author = "Kaja Sitkowska and Hoes, \{Martijn F.\} and Lerch, \{Michael M.\} and Lameijer, \{Lucien N.\} and \{van der Meer\}, Peter and Wiktor Szymanski and Feringa, \{Ben L.\}",

year = "2020",

month = may,

day = "21",

doi = "10.1039/d0cc02178d",

language = "English",

volume = "56",

pages = "5480--5483",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

number = "41",

}

TY - JOUR

T1 - Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm

AU - Sitkowska, Kaja

AU - Hoes, Martijn F.

AU - Lerch, Michael M.

AU - Lameijer, Lucien N.

AU - van der Meer, Peter

AU - Szymanski, Wiktor

AU - Feringa, Ben L.

PY - 2020/5/21

Y1 - 2020/5/21

N2 - Control of biological function by the use of photoremovable protecting groups (PPGs) is a gateway towards many new medical developments. Herein, we report the synthesis and application of efficient and biocompatible BODIPY-based photoprotecting groups for amines, which are cleavable with red light in the phototherapeutic window region (λ > 650 nm). We use the most promising PPG for the protection of dopamine and apply it to control the beating frequency of human cardiomyocytes.

AB - Control of biological function by the use of photoremovable protecting groups (PPGs) is a gateway towards many new medical developments. Herein, we report the synthesis and application of efficient and biocompatible BODIPY-based photoprotecting groups for amines, which are cleavable with red light in the phototherapeutic window region (λ > 650 nm). We use the most promising PPG for the protection of dopamine and apply it to control the beating frequency of human cardiomyocytes.

KW - PHOTOREMOVABLE PROTECTING GROUPS

KW - PHOTOACTIVATABLE PRODRUGS

KW - REACTION-MECHANISMS

KW - OPTICAL CONTROL

KW - CROSS-SECTIONS

KW - WAVELENGTH

KW - REACTIVITY

KW - DOPAMINE

KW - RELEASE

U2 - 10.1039/d0cc02178d

DO - 10.1039/d0cc02178d

M3 - Article

SN - 1359-7345

VL - 56

SP - 5480

EP - 5483

JO - Chemical Communications

JF - Chemical Communications

IS - 41

ER -

Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm

Samenvatting

Toegang tot document

Handle.net

Vingerafdruk

Citeer dit