Red-light-sensitive BODIPY photoprotecting groups for amines and their biological application in controlling heart rhythm

Kaja Sitkowska, Martijn F. Hoes, Michael M. Lerch, Lucien N. Lameijer, Peter van der Meer, Wiktor Szymanski, Ben L. Feringa

OnderzoeksoutputAcademicpeer review

30 Citaten (Scopus)
72 Downloads (Pure)

Samenvatting

Control of biological function by the use of photoremovable protecting groups (PPGs) is a gateway towards many new medical developments. Herein, we report the synthesis and application of efficient and biocompatible BODIPY-based photoprotecting groups for amines, which are cleavable with red light in the phototherapeutic window region (λ > 650 nm). We use the most promising PPG for the protection of dopamine and apply it to control the beating frequency of human cardiomyocytes.

Originele taal-2English
Pagina's (van-tot)5480-5483
Aantal pagina's4
TijdschriftChemical Communications
Volume56
Nummer van het tijdschrift41
DOI's
StatusPublished - 21-mei-2020

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