Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia

Karim El Harchaoui; Remco Franssen; G. Kees Hovingh; Radjesh J. Bisoendial; Frans Stellaard; Folkert Kuipers; John J. P. Kastelein; Jan Albert Kuivenhoven; Erik S. G. Stroes; Albert K. Groen

doi:10.1016/j.atherosclerosis.2009.06.022

Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia

Karim El Harchaoui, Remco Franssen, G. Kees Hovingh, Radjesh J. Bisoendial, Frans Stellaard, Folkert Kuipers, John J. P. Kastelein, Jan Albert Kuivenhoven, Erik S. G. Stroes, Albert K. Groen^*

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

11 Citaten (Scopus)

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BACKGROUND: Fecal bile acid and neutral sterol excretion are the obligate endpoints of the reverse cholesterol transport pathway (RCT). In studies in mice, no evidence was found for a relation between HDL-cholesterol (HDL-c) levels and fecal sterol excretion. In this study, we have evaluated this relationship in patients with isolated low HDL-c versus controls.

RESULTS: Fecal sterol excretion was studied in 12 subjects with familial hypoalphalipoproteinemia (FHA) and 11 healthy controls. Compared to the controls (8.9+/-6.3mg/kg/day), neutral sterol excretion was significantly lower in the FHA group (4.0+/-2.4mg/kg/day). Fecal bile acid excretion showed a similar pattern. Across the groups, a strong positive correlation between HDL-c and fecal neutral sterol excretion was found (r=0.53; p=0.01).

CONCLUSIONS: Isolated low HDL-c levels in humans are associated with reduced fecal sterol excretion suggesting that in humans HDL regulates the final step in the RCT pathway at low HDL-c levels.

Originele taal-2	English
Pagina's (van-tot)	614-616
Aantal pagina's	3
Tijdschrift	Atherosclerosis
Volume	207
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1016/j.atherosclerosis.2009.06.022
Status	Published - dec.-2009

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@article{134543eb20f44d0db7edfb0a3f479720,

title = "Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia",

abstract = "BACKGROUND: Fecal bile acid and neutral sterol excretion are the obligate endpoints of the reverse cholesterol transport pathway (RCT). In studies in mice, no evidence was found for a relation between HDL-cholesterol (HDL-c) levels and fecal sterol excretion. In this study, we have evaluated this relationship in patients with isolated low HDL-c versus controls.RESULTS: Fecal sterol excretion was studied in 12 subjects with familial hypoalphalipoproteinemia (FHA) and 11 healthy controls. Compared to the controls (8.9+/-6.3mg/kg/day), neutral sterol excretion was significantly lower in the FHA group (4.0+/-2.4mg/kg/day). Fecal bile acid excretion showed a similar pattern. Across the groups, a strong positive correlation between HDL-c and fecal neutral sterol excretion was found (r=0.53; p=0.01).CONCLUSIONS: Isolated low HDL-c levels in humans are associated with reduced fecal sterol excretion suggesting that in humans HDL regulates the final step in the RCT pathway at low HDL-c levels.",

keywords = "REVERSE CHOLESTEROL TRANSPORT, A-I, ABSORPTION, LIPOPROTEINS, INHIBITION, HUMANS",

author = "{El Harchaoui}, Karim and Remco Franssen and Hovingh, {G. Kees} and Bisoendial, {Radjesh J.} and Frans Stellaard and Folkert Kuipers and Kastelein, {John J. P.} and Kuivenhoven, {Jan Albert} and Stroes, {Erik S. G.} and Groen, {Albert K.}",

year = "2009",

month = dec,

doi = "10.1016/j.atherosclerosis.2009.06.022",

language = "English",

volume = "207",

pages = "614--616",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "ELSEVIER IRELAND LTD",

number = "2",

}

TY - JOUR

T1 - Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia

AU - El Harchaoui, Karim

AU - Franssen, Remco

AU - Hovingh, G. Kees

AU - Bisoendial, Radjesh J.

AU - Stellaard, Frans

AU - Kuipers, Folkert

AU - Kastelein, John J. P.

AU - Kuivenhoven, Jan Albert

AU - Stroes, Erik S. G.

AU - Groen, Albert K.

PY - 2009/12

Y1 - 2009/12

N2 - BACKGROUND: Fecal bile acid and neutral sterol excretion are the obligate endpoints of the reverse cholesterol transport pathway (RCT). In studies in mice, no evidence was found for a relation between HDL-cholesterol (HDL-c) levels and fecal sterol excretion. In this study, we have evaluated this relationship in patients with isolated low HDL-c versus controls.RESULTS: Fecal sterol excretion was studied in 12 subjects with familial hypoalphalipoproteinemia (FHA) and 11 healthy controls. Compared to the controls (8.9+/-6.3mg/kg/day), neutral sterol excretion was significantly lower in the FHA group (4.0+/-2.4mg/kg/day). Fecal bile acid excretion showed a similar pattern. Across the groups, a strong positive correlation between HDL-c and fecal neutral sterol excretion was found (r=0.53; p=0.01).CONCLUSIONS: Isolated low HDL-c levels in humans are associated with reduced fecal sterol excretion suggesting that in humans HDL regulates the final step in the RCT pathway at low HDL-c levels.

AB - BACKGROUND: Fecal bile acid and neutral sterol excretion are the obligate endpoints of the reverse cholesterol transport pathway (RCT). In studies in mice, no evidence was found for a relation between HDL-cholesterol (HDL-c) levels and fecal sterol excretion. In this study, we have evaluated this relationship in patients with isolated low HDL-c versus controls.RESULTS: Fecal sterol excretion was studied in 12 subjects with familial hypoalphalipoproteinemia (FHA) and 11 healthy controls. Compared to the controls (8.9+/-6.3mg/kg/day), neutral sterol excretion was significantly lower in the FHA group (4.0+/-2.4mg/kg/day). Fecal bile acid excretion showed a similar pattern. Across the groups, a strong positive correlation between HDL-c and fecal neutral sterol excretion was found (r=0.53; p=0.01).CONCLUSIONS: Isolated low HDL-c levels in humans are associated with reduced fecal sterol excretion suggesting that in humans HDL regulates the final step in the RCT pathway at low HDL-c levels.

KW - REVERSE CHOLESTEROL TRANSPORT

KW - A-I

KW - ABSORPTION

KW - LIPOPROTEINS

KW - INHIBITION

KW - HUMANS

U2 - 10.1016/j.atherosclerosis.2009.06.022

DO - 10.1016/j.atherosclerosis.2009.06.022

M3 - Article

C2 - 19616211

SN - 0021-9150

VL - 207

SP - 614

EP - 616

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia

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