Regio- and Enantioselective Copper-Catalyzed Allylic Alkylation of Ortho-Substituted Cinnamyl Bromides with Grignard Reagents

Nathalie C. van der Molen, Theodora D. Tiemersma-Wegman, Martín Fañanás-Mastral, Ben L. Feringa

OnderzoeksoutputAcademicpeer review

6 Citaten (Scopus)
22 Downloads (Pure)

Samenvatting

A highly efficient method for the copper-catalyzed asymmetric allylic alkylation of ortho-substituted cinnamyl bromides with Grignard reagents is reported. The use of a catalytic system comprising CuBr center dot SMe2 and TaniaPhos as chiral ligands gives rise to a range of branched products with excellent regio- and enantioselectivity.

Originele taal-2English
Pagina's (van-tot)4981-4984
Aantal pagina's4
TijdschriftJournal of Organic Chemistry
Volume80
Nummer van het tijdschrift10
DOI's
StatusPublished - 15-mei-2015

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