Regional variations in human milk oligosaccharides in Vietnam suggest FucTx activity besides FucT2 and FucT3

Sander S. van Leeuwen*, Eline Stoutjesdijk, Geert A. ten Kate, Anne Schaafsma, Janneke Dijck-Brouwer, Frits A. J. Muskiet, Lubbert Dijkhuizen

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

26 Citaten (Scopus)
217 Downloads (Pure)

Samenvatting

Breastfeeding is the normal way of providing young infants with the nutrients they need for healthy growth and development (WHO). Human milk oligosaccharides (hMOS) constitute a highly important class of nutrients that are attracting strong attention in recent years. Several studies have indicated that hMOS have prebiotic properties, but also are effective in anti-adhesion of pathogens, modulating the immune system and providing nutrients for brain growth and development. Most of the latter functions seem to be linked to the presence of fucose-containing immunodeterminant epitopes, and Neu5Ac-bearing oligosaccharides. Analysis of hMOS isolated from 101 mothers' milk showed regional variation in Lewis-and Secretor based immunodeterminants. Lewis-negative milk groups could be sub-divided into two sub-groups, based on the activity of a third and hitherto unidentified fucosyltransferase enzyme. Analysis of hMOS remaining in faeces showed three sub-groups based on hMOS surviving passage through the gut, full consumption, specific partial consumption and nonspecific partial consumption, fitting previous findings.

Originele taal-2English
Artikelnummer16790
Aantal pagina's11
TijdschriftScientific Reports
Volume8
Nummer van het tijdschrift1
DOI's
StatusPublished - 14-nov.-2018

Citeer dit