Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies

Wijtske Annema, Uwe J. F. Tietge*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

72 Citaten (Scopus)
226 Downloads (Pure)


Plasma levels of high density lipoprotein (HDL) cholesterol are strongly inversely correlated to the risk of atherosclerotic cardiovascular disease. A major recognized functional property of HDL particles is to elicit cholesterol efflux and consequently mediate reverse cholesterol transport (RCT). The recent introduction of a surrogate method aiming at determining specifically RCT from the macrophage compartment has facilitated research on the different components and pathways relevant for RCT. The current review provides a comprehensive overview of studies carried out on macrophage-specific RCT including a quick reference guide of available data. Knowledge and insights gained on the regulation of the RCT pathway are summarized. A discussion of methodological issues as well as of the respective relevance of specific pathways for RCT is also included.

Originele taal-2English
Aantal pagina's18
TijdschriftNutrition & Metabolism
StatusPublished - 29-mrt.-2012

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