Relationship between gut microbiota and circulating metabolites in population-based cohorts

Dina Vojinovic*, Djawad Radjabzadeh, Alexander Kurilshikov, Najaf Amin, Cisca Wijmenga, Lude Franke, M Arfan Ikram, Andre G Uitterlinden, Alexandra Zhernakova, Jingyuan Fu, Robert Kraaij, Cornelia M van Duijn

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

27 Citaten (Scopus)
107 Downloads (Pure)


Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles into more details. Here, we examine the impact of gut microbiota on circulating metabolites measured by Nuclear Magnetic Resonance technology in 2309 individuals from the Rotterdam Study and the LifeLines-DEEP cohort. We assess the relationship between gut microbiota and metabolites by linear regression analysis while adjusting for age, sex, body-mass index, technical covariates, medication use, and multiple testing. We report an association of 32 microbial families and genera with very-low-density and high-density subfractions, serum lipid measures, glycolysis-related metabolites, ketone bodies, amino acids, and acute-phase reaction markers. These observations provide insights into the role of microbiota in host metabolism and support the potential of gut microbiota as a target for therapeutic and preventive interventions.

Originele taal-2English
Aantal pagina's7
TijdschriftNature Communications
Nummer van het tijdschrift1
StatusPublished - 20-dec-2019

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