Relationships between brain water content and diffusion tensor imaging parameters (apparent diffusion coefficient and fractional anisotropy) in multiple sclerosis

PE Sijens*, R Irwan, JH Potze, JP Mostert, J De Keyser, M Oudkerk

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

14 Citaten (Scopus)


Fifteen multiple sclerosis patients were examined by diffusion tensor imaging (DTI) to determine fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in a superventricular volume of interest of 8x8x2 cm(3) containing gray matter (GM) and white matter (WM) tissue. Point resolved spectroscopy 2D-chemical shift imaging of the same volume was performed without water suppression. The water contents and DTI parameters in 64 voxels of 2 cm(3) were compared. The water content was increased in patients compared with controls (GM: 244 +/- 21 vs. 194 +/- 10 a.u.; WM: 245 +/- 32 vs. 190 +/- 11 a.u.), FA decreased (GM: 0.226 +/- 0.038 vs. 0.270 +/- 0.020; WM: 0.337 +/- 0.044 vs. 0.402 +/- 0.011) and ADC increased [GM: 1134 +/- 203 vs. 899 +/- 28 (x10(-6) mm(2)/s); WM: 901 +/- 138 vs. 751 +/- 17 (x10(6) mm(2)/s)]. Correlations of water content with FA and ADC in WM were strong (r=-0.68, P <0.02; r=0.75; P <0.01, respectively); those in GM were weaker (r=-0.50, P <0.05; r=0.45, P <0.1, respectively). Likewise, FA and ADC were more strongly correlated in WM (r=-0.88; P <0.00001) than in GM (r=-0.69, P <0.01). The demonstrated relationship between DTI parameters and water content in multiple sclerosis patients suggests a potential for therapy monitoring in normal-appearing brain tissue.

Originele taal-2English
Pagina's (van-tot)898-904
Aantal pagina's7
TijdschriftEuropean Radiology
Nummer van het tijdschrift4
StatusPublished - apr.-2006

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