Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria

Peter A Bron*, Barbara Marcelli, Joyce Mulder, Simon van der Els, Luiza P Morawska, Oscar P Kuipers, Jan Kok, Michiel Kleerebezem

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

13 Citaten (Scopus)
650 Downloads (Pure)


The ever-expanding genomic insight in natural diversity of lactic acid bacteria (LAB) has revived the industrial interest in traditional and natural genetic mobilization methodologies. Here, we review recent advances in horizontal gene transfer processes in LAB, including natural competence, conjugation, and phage transduction. In addition, we envision the possibilities for industrial strain improvement arising from the recent discoveries of molecular exchanges between bacteria through nanotubes and extracellular vesicles, as well as the constantly expanding genome editing possibilities using the CRISPR-Cas technology.

Originele taal-2English
Pagina's (van-tot)61-68
Aantal pagina's8
TijdschriftCurrent Opinion in Biotechnology
Vroegere onlinedatum11-okt-2018
StatusPublished - apr-2019

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