Renal fibrosis in precision-cut kidney slices

Elisabeth G. D. Stribos, Jan-Luuk Hillebrands, Peter Olinga*, Henricus A. M. Mutsaers

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

14 Citaten (Scopus)

Samenvatting

Chronic kidney disease (CKD) is associated with renal fibrosis, a pathological process that is characterized by excessive accumulation of extracellular matrix proteins resulting in loss of organ architecture and function. Currently, renal transplantation and dialysis are the sole treatment options for advanced CKD, yet these therapies have limited impact on fibrogenesis. Even though antifibrotic therapies are being developed, the search for effective antifibrotic drugs is being hampered by the lack of appropriate cell and animal models to study renal fibrosis. In vitro models lack cellular heterogeneity whereas in vivo models do not fully reflect human pathology. Precision-cut tissue slices, prepared from human or rodent tissue, provide a unique ex vivo model system that captures the complexity of organs, and they are widely used for ADME/Tox drug testing. Moreover, precision-cut kidney slices (PCKS) have been recently established as a useful model to study renal fibrosis. This review summarizes the currently available models for renal fibrosis, describes the wide array of possibilities with PCKS and shows its role in the search for antifibrotic drugs. (C) 2016 Elsevier B.V. All rights reserved.

Originele taal-2English
Pagina's (van-tot)57-61
Aantal pagina's5
TijdschriftEuropean Journal of Pharmacology
Volume790
DOI's
StatusPublished - 5-nov-2016

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