Responsive DNA G-quadruplex micelles

Liliana Cozzoli, Lorina Gjonaj, Marc C A Stuart, Bert Poolman, Gerard Roelfes

OnderzoeksoutputAcademicpeer review

15 Citaten (Scopus)
247 Downloads (Pure)

Samenvatting

A novel and versatile design of DNA-lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.

Originele taal-2English
Pagina's (van-tot)260-263
Aantal pagina's4
TijdschriftChemical communications (Cambridge, England)
Volume54
Vroegere onlinedatum6-dec-2017
DOI's
StatusPublished - 11-jan-2018

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