Responsive DNA G-quadruplex micelles

Liliana Cozzoli; Lorina Gjonaj; Marc C A Stuart; Bert Poolman; Gerard Roelfes

doi:10.1039/c7cc07899d

Responsive DNA G-quadruplex micelles

Liliana Cozzoli, Lorina Gjonaj, Marc C A Stuart, Bert Poolman, Gerard Roelfes

Onderzoeksoutput › Academic › peer review

15 Citaten (Scopus)

247 Downloads (Pure)

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A novel and versatile design of DNA-lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.

Originele taal-2	English
Pagina's (van-tot)	260-263
Aantal pagina's	4
Tijdschrift	Chemical communications (Cambridge, England)
Volume	54
Vroegere onlinedatum	6-dec-2017
DOI's	https://doi.org/10.1039/c7cc07899d
Status	Published - 11-jan-2018

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10.1039/c7cc07899d

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title = "Responsive DNA G-quadruplex micelles",

abstract = "A novel and versatile design of DNA-lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.",

keywords = "micelles, DNA G-quadruplex, DNA-lipid conjugates, hybridization, cargo release, RELEASE, COMPLEX, ENERGY-TRANSFER, NILE RED, APTAMER, STABILITY, SEQUENCES, SWITCHES",

author = "Liliana Cozzoli and Lorina Gjonaj and Stuart, {Marc C A} and Bert Poolman and Gerard Roelfes",

year = "2018",

month = jan,

day = "11",

doi = "10.1039/c7cc07899d",

language = "English",

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journal = "Chemical Communications (Cambridge, United Kingdom)",

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T1 - Responsive DNA G-quadruplex micelles

AU - Cozzoli, Liliana

AU - Gjonaj, Lorina

AU - Stuart, Marc C A

AU - Poolman, Bert

AU - Roelfes, Gerard

PY - 2018/1/11

Y1 - 2018/1/11

N2 - A novel and versatile design of DNA-lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.

AB - A novel and versatile design of DNA-lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.

KW - micelles

KW - DNA G-quadruplex

KW - DNA-lipid conjugates

KW - hybridization

KW - cargo release

KW - RELEASE

KW - COMPLEX

KW - ENERGY-TRANSFER

KW - NILE RED

KW - APTAMER

KW - STABILITY

KW - SEQUENCES

KW - SWITCHES

U2 - 10.1039/c7cc07899d

DO - 10.1039/c7cc07899d

M3 - Article

C2 - 29231221

VL - 54

SP - 260

EP - 263

JO - Chemical Communications (Cambridge, United Kingdom)

JF - Chemical Communications (Cambridge, United Kingdom)

SN - 1359-7345

ER -