Restoration of the CD4 T cell compartment after long-term highly active Antiretroviral therapy without phenotypical signs of accelerated immunological aging

Nienke Vrisekoop, Rogier van Gent, Anne Bregje de Boer, Sigrid A. Otto, Jan C. C. Borleffs, Radjin Stemgrover, Jan M. Prins, Taco W. Kuijpers, Tom F. W. Wolfs, Sibyl P. M. Geelen, Irma Vulto, Peter Lansdorp, Kiki Tesselaar, Jose A. M. Borghans, Frank Miedema*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

50 Citaten (Scopus)


It remains uncertain whether full T cell reconstitution can be established in HIV-infected children and adults with long-term sustained virological control by highly active antiretroviral therapy (HAART). In this study, we comprehensively analyzed various phenotypical markers of CD4 T cell recovery. In addition to measuring T cell activation and proliferation markers, CD4 T cell generation and aging of the CD4 T cell compartment were assessed by measuring TCR excision circles and the fraction of CD31-expressing naive CD4 T cells. In all children and in adults with relatively high CD4 T cell counts at start of therapy (>200 cells/mu l), total CD4 T cell numbers normalized within I year of therapy. After long-term HAART (4.4-9.6 years), naive CD4 T cell counts had normalized in both groups. Although in adults with low baseline CD4 T cell counts (

Originele taal-2English
Pagina's (van-tot)1573-1581
Aantal pagina's9
TijdschriftJournal of Immunology
Nummer van het tijdschrift2
StatusPublished - 15-jul-2008
Extern gepubliceerdJa

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