Reticulophagy and ribophagy: regulated degradation of protein production factories

Eduardo Cebollero, Fulvio Reggiori, Claudine Kraft

OnderzoeksoutputAcademicpeer review

99 Citaten (Scopus)
23 Downloads (Pure)

Samenvatting

During autophagy, cytosol, protein aggregates, and organelles are sequestered into double-membrane vesicles called autophagosomes and delivered to the lysosome/vacuole for breakdown and recycling of their basic components. In all eukaryotes this pathway is important for adaptation to stress conditions such as nutrient deprivation, as well as to regulate intracellular homeostasis by adjusting organelle number and clearing damaged structures. For a long time, starvation-induced autophagy has been viewed as a nonselective transport pathway; however, recent studies have revealed that autophagy is able to selectively engulf specific structures, ranging from proteins to entire organelles. In this paper, we discuss recent findings on the mechanisms and physiological implications of two selective types of autophagy: ribophagy, the specific degradation of ribosomes, and reticulophagy, the selective elimination of portions of the ER.

Originele taal-2English
Artikelnummer182834
Aantal pagina's9
TijdschriftInternational Journal of Cell Biology
Volume2012
DOI's
StatusPublished - 2012
Extern gepubliceerdJa

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