Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

M P M Boks, T Rietkerk, M H van de Beek, I E Sommer, T J de Koning, R S Kahn

Onderzoeksoutputpeer review

72 Citaten (Scopus)

Samenvatting

We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.

Originele taal-2English
Pagina's (van-tot)567-72
Aantal pagina's6
TijdschriftEuropean Neuropsychopharmacology
Volume17
Nummer van het tijdschrift9
DOI's
StatusPublished - sep.-2007
Extern gepubliceerdJa

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