Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele

T. J.M. Van Der Cammen; C. J. Verschoor; C. P.M. Van Loon; F. Van Harskamp; I. De Koning; W. J. Schudel; A. J.C. Slooter; C. Van Broeckhoven; C. M. Van Duijn

doi:10.1111/j.1532-5415.1998.tb02749.x

Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele

T. J.M. Van Der Cammen^*
, C. J. Verschoor
, C. P.M. Van Loon
, F. Van Harskamp
, I. De Koning
, W. J. Schudel
, A. J.C. Slooter
, C. Van Broeckhoven
, C. M. Van Duijn

^*Corresponding author voor dit werk

Onderzoeksoutput: Article › Academic › peer review

23 Citaten (Scopus)

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OBJECTIVE: To examine the association between the APOE genotype and cardiovascular disease in Alzheimer's disease (AD) patients.

DESIGN: Case register study of 100 consecutive referrals to a Memory Clinic where type of dementia and cardiovascular comorbidity were diagnosed and APOE genotype was determined.

SETTING: The Memory Clinic, University Hospital Rotterdam Dijkzigt.

PARTICIPANTS: One hundred Memory Clinic patients, 59 to 91 years of age, who attended the Memory Clinic in the period between January 1994 and March 1996.

MEASUREMENTS: Relative risk of cardiovascular morbidity in probable AD, based on clinical and ECG findings.

RESULTS: The diagnosis of probable AD was more frequent in APOE*4 allele-carrying AD patients. When comparing homozygotes for APOE*4 with homozygotes for APOE*3, a nine-fold increase in prevalence of cardiac ischemia on ECG was found in the former. When grouping parameters of left ventricular dysfunction, the prevalence was 7.2 (95% confidence interval 1.2-42.6) times greater in probable Alzheimer patients with APOE4/4.

CONCLUSIONS: In patients with probable AD, APOE*4 is associated with cardiac disease indicative of left ventricular dysfunction.

Originele taal-2	English
Pagina's (van-tot)	962-967
Aantal pagina's	6
Tijdschrift	Journal of the American Geriatrics Society
Volume	46
Nummer van het tijdschrift	8
DOI's	https://doi.org/10.1111/j.1532-5415.1998.tb02749.x
Status	Published - aug.-1998
Extern gepubliceerd	Ja

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Van Der Cammen, T. J. M., Verschoor, C. J., Van Loon, C. P. M., Van Harskamp, F., De Koning, I., Schudel, W. J., Slooter, A. J. C., Van Broeckhoven, C., & Van Duijn, C. M. (1998). Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele. Journal of the American Geriatrics Society, 46(8), 962-967. https://doi.org/10.1111/j.1532-5415.1998.tb02749.x

@article{38c2ca82f5064a62ad352872ce841f33,

title = "Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele",

abstract = "OBJECTIVE: To examine the association between the APOE genotype and cardiovascular disease in Alzheimer's disease (AD) patients. DESIGN: Case register study of 100 consecutive referrals to a Memory Clinic where type of dementia and cardiovascular comorbidity were diagnosed and APOE genotype was determined. SETTING: The Memory Clinic, University Hospital Rotterdam Dijkzigt. PARTICIPANTS: One hundred Memory Clinic patients, 59 to 91 years of age, who attended the Memory Clinic in the period between January 1994 and March 1996. MEASUREMENTS: Relative risk of cardiovascular morbidity in probable AD, based on clinical and ECG findings. RESULTS: The diagnosis of probable AD was more frequent in APOE*4 allele-carrying AD patients. When comparing homozygotes for APOE*4 with homozygotes for APOE*3, a nine-fold increase in prevalence of cardiac ischemia on ECG was found in the former. When grouping parameters of left ventricular dysfunction, the prevalence was 7.2 (95\% confidence interval 1.2-42.6) times greater in probable Alzheimer patients with APOE4/4. CONCLUSIONS: In patients with probable AD, APOE*4 is associated with cardiac disease indicative of left ventricular dysfunction.",

author = "\{Van Der Cammen\}, \{T. J.M.\} and Verschoor, \{C. J.\} and \{Van Loon\}, \{C. P.M.\} and \{Van Harskamp\}, F. and \{De Koning\}, I. and Schudel, \{W. J.\} and Slooter, \{A. J.C.\} and \{Van Broeckhoven\}, C. and \{Van Duijn\}, \{C. M.\}",

year = "1998",

month = aug,

doi = "10.1111/j.1532-5415.1998.tb02749.x",

language = "English",

volume = "46",

pages = "962--967",

journal = "Journal of the American Geriatrics Society",

issn = "0002-8614",

publisher = "Wiley",

number = "8",

}

Van Der Cammen, TJM, Verschoor, CJ, Van Loon, CPM, Van Harskamp, F, De Koning, I, Schudel, WJ, Slooter, AJC, Van Broeckhoven, C & Van Duijn, CM 1998, 'Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele', Journal of the American Geriatrics Society, vol. 46, nr. 8, blz. 962-967. https://doi.org/10.1111/j.1532-5415.1998.tb02749.x

TY - JOUR

T1 - Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele

AU - Van Der Cammen, T. J.M.

AU - Verschoor, C. J.

AU - Van Loon, C. P.M.

AU - Van Harskamp, F.

AU - De Koning, I.

AU - Schudel, W. J.

AU - Slooter, A. J.C.

AU - Van Broeckhoven, C.

AU - Van Duijn, C. M.

PY - 1998/8

Y1 - 1998/8

N2 - OBJECTIVE: To examine the association between the APOE genotype and cardiovascular disease in Alzheimer's disease (AD) patients. DESIGN: Case register study of 100 consecutive referrals to a Memory Clinic where type of dementia and cardiovascular comorbidity were diagnosed and APOE genotype was determined. SETTING: The Memory Clinic, University Hospital Rotterdam Dijkzigt. PARTICIPANTS: One hundred Memory Clinic patients, 59 to 91 years of age, who attended the Memory Clinic in the period between January 1994 and March 1996. MEASUREMENTS: Relative risk of cardiovascular morbidity in probable AD, based on clinical and ECG findings. RESULTS: The diagnosis of probable AD was more frequent in APOE*4 allele-carrying AD patients. When comparing homozygotes for APOE*4 with homozygotes for APOE*3, a nine-fold increase in prevalence of cardiac ischemia on ECG was found in the former. When grouping parameters of left ventricular dysfunction, the prevalence was 7.2 (95% confidence interval 1.2-42.6) times greater in probable Alzheimer patients with APOE4/4. CONCLUSIONS: In patients with probable AD, APOE*4 is associated with cardiac disease indicative of left ventricular dysfunction.

AB - OBJECTIVE: To examine the association between the APOE genotype and cardiovascular disease in Alzheimer's disease (AD) patients. DESIGN: Case register study of 100 consecutive referrals to a Memory Clinic where type of dementia and cardiovascular comorbidity were diagnosed and APOE genotype was determined. SETTING: The Memory Clinic, University Hospital Rotterdam Dijkzigt. PARTICIPANTS: One hundred Memory Clinic patients, 59 to 91 years of age, who attended the Memory Clinic in the period between January 1994 and March 1996. MEASUREMENTS: Relative risk of cardiovascular morbidity in probable AD, based on clinical and ECG findings. RESULTS: The diagnosis of probable AD was more frequent in APOE*4 allele-carrying AD patients. When comparing homozygotes for APOE*4 with homozygotes for APOE*3, a nine-fold increase in prevalence of cardiac ischemia on ECG was found in the former. When grouping parameters of left ventricular dysfunction, the prevalence was 7.2 (95% confidence interval 1.2-42.6) times greater in probable Alzheimer patients with APOE4/4. CONCLUSIONS: In patients with probable AD, APOE*4 is associated with cardiac disease indicative of left ventricular dysfunction.

UR - https://www.scopus.com/pages/publications/0031859720

U2 - 10.1111/j.1532-5415.1998.tb02749.x

DO - 10.1111/j.1532-5415.1998.tb02749.x

M3 - Article

C2 - 9706883

AN - SCOPUS:0031859720

SN - 0002-8614

VL - 46

SP - 962

EP - 967

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

IS - 8

ER -

Risk of left ventricular dysfunction in patients with probable Alzheimer's disease with APOE*4 allele

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