Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days

Frederik J. R. Hermans; Merel M. C. Bruijn; Jolande Y. Vis; Femke F. Wilms; Martijn A. Oudijk; Martina M. Porath; Hubertina C. J. Scheepers; Kitty W. M. Bloemenkamp; Caroline J. Bax; Jerome M. J. Cornette; Bas W. A. Nij Bijvanck; Maureen T. M. Franssen; Frank P. H. A. Vandenbussche; Marjolein Kok; William A. Grobman; Joris A. M. Van Der Post; Patrick M. M. Bossuyt; Brent C. Opmeer; Ben Willem J. Mol; Ewoud Schuit; Gert-Jan Van Baaren

doi:10.1111/aogs.12643

Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days

Frederik J. R. Hermans^*, Merel M. C. Bruijn, Jolande Y. Vis, Femke F. Wilms, Martijn A. Oudijk, Martina M. Porath, Hubertina C. J. Scheepers, Kitty W. M. Bloemenkamp, Caroline J. Bax, Jerome M. J. Cornette, Bas W. A. Nij Bijvanck, Maureen T. M. Franssen, Frank P. H. A. Vandenbussche, Marjolein Kok, William A. Grobman, Joris A. M. Van Der Post, Patrick M. M. Bossuyt, Brent C. Opmeer, Ben Willem J. Mol, Ewoud SchuitGert-Jan Van Baaren

^*Corresponding author voor dit werk

Reproductive Origins of Adult Health and Disease (ROAHD)

Onderzoeksoutput › Academic › peer review

15 Citaten (Scopus)

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ObjectiveTo stratify the risk of spontaneous preterm delivery using cervical length (CL) and fetal fibronectin (fFN) in women with threatened preterm labor who remained pregnant after 7days.

DesignProspective observational study.

SettingNationwide cohort of women with threatened preterm labor from the Netherlands.

PopulationWomen with threatened preterm labor between 24 and 34weeks with a valid CL and fFN measurement and remaining pregnant 7days after admission.

MethodsKaplan-Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR) for spontaneous delivery.

Main outcome measuresSpontaneous delivery between 7 and 14days after initial presentation and spontaneous preterm delivery before 34weeks.

ResultsThe risk of delivery between 7 and 14days was significantly increased for women with a CL

ConclusionsIn women remaining pregnant 7days after threatened preterm labor, CL and fFN results can be used in risk stratification for spontaneous delivery.

Originele taal-2	English
Pagina's (van-tot)	715-721
Aantal pagina's	7
Tijdschrift	Acta Obstetricia et Gynecologica Scandinavica
Volume	94
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1111/aogs.12643
Status	Published - jul.-2015

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Hermans, F. J. R., Bruijn, M. M. C., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Porath, M. M., Scheepers, H. C. J., Bloemenkamp, K. W. M., Bax, C. J., Cornette, J. M. J., Bijvanck, B. W. A. N., Franssen, M. T. M., Vandenbussche, F. P. H. A., Kok, M., Grobman, W. A., Van Der Post, J. A. M., Bossuyt, P. M. M., Opmeer, B. C., Mol, B. W. J., ... Van Baaren, G.-J. (2015). Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days. Acta Obstetricia et Gynecologica Scandinavica, 94(7), 715-721. https://doi.org/10.1111/aogs.12643

@article{f6cacb92db00408bb01a73ab4b936683,

title = "Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days",

abstract = "ObjectiveTo stratify the risk of spontaneous preterm delivery using cervical length (CL) and fetal fibronectin (fFN) in women with threatened preterm labor who remained pregnant after 7days.DesignProspective observational study.SettingNationwide cohort of women with threatened preterm labor from the Netherlands.PopulationWomen with threatened preterm labor between 24 and 34weeks with a valid CL and fFN measurement and remaining pregnant 7days after admission.MethodsKaplan-Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR) for spontaneous delivery.Main outcome measuresSpontaneous delivery between 7 and 14days after initial presentation and spontaneous preterm delivery before 34weeks.ResultsThe risk of delivery between 7 and 14days was significantly increased for women with a CLConclusionsIn women remaining pregnant 7days after threatened preterm labor, CL and fFN results can be used in risk stratification for spontaneous delivery.",

keywords = "Threatened preterm labor, fetal fibronectin, cervical length, pregnancy complications, risk, prediction, spontaneous preterm delivery, ANTENATAL CORTICOSTEROIDS, UTERINE CONTRACTIONS, BIRTH, PHARMACOKINETICS, PREDICTOR, TOCOLYSIS, ACCURACY, OUTCOMES, COHORT",

author = "Hermans, {Frederik J. R.} and Bruijn, {Merel M. C.} and Vis, {Jolande Y.} and Wilms, {Femke F.} and Oudijk, {Martijn A.} and Porath, {Martina M.} and Scheepers, {Hubertina C. J.} and Bloemenkamp, {Kitty W. M.} and Bax, {Caroline J.} and Cornette, {Jerome M. J.} and Bijvanck, {Bas W. A. Nij} and Franssen, {Maureen T. M.} and Vandenbussche, {Frank P. H. A.} and Marjolein Kok and Grobman, {William A.} and {Van Der Post}, {Joris A. M.} and Bossuyt, {Patrick M. M.} and Opmeer, {Brent C.} and Mol, {Ben Willem J.} and Ewoud Schuit and {Van Baaren}, Gert-Jan",

year = "2015",

month = jul,

doi = "10.1111/aogs.12643",

language = "English",

volume = "94",

pages = "715--721",

journal = "Acta Obstetricia et Gynecologica Scandinavica",

issn = "0001-6349",

publisher = "Wiley",

number = "7",

}

Hermans, FJR, Bruijn, MMC, Vis, JY, Wilms, FF, Oudijk, MA, Porath, MM, Scheepers, HCJ, Bloemenkamp, KWM, Bax, CJ, Cornette, JMJ, Bijvanck, BWAN, Franssen, MTM, Vandenbussche, FPHA, Kok, M, Grobman, WA, Van Der Post, JAM, Bossuyt, PMM, Opmeer, BC, Mol, BWJ, Schuit, E & Van Baaren, G-J 2015, 'Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days', Acta Obstetricia et Gynecologica Scandinavica, vol. 94, nr. 7, blz. 715-721. https://doi.org/10.1111/aogs.12643

TY - JOUR

T1 - Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days

AU - Hermans, Frederik J. R.

AU - Bruijn, Merel M. C.

AU - Vis, Jolande Y.

AU - Wilms, Femke F.

AU - Oudijk, Martijn A.

AU - Porath, Martina M.

AU - Scheepers, Hubertina C. J.

AU - Bloemenkamp, Kitty W. M.

AU - Bax, Caroline J.

AU - Cornette, Jerome M. J.

AU - Bijvanck, Bas W. A. Nij

AU - Franssen, Maureen T. M.

AU - Vandenbussche, Frank P. H. A.

AU - Kok, Marjolein

AU - Grobman, William A.

AU - Van Der Post, Joris A. M.

AU - Bossuyt, Patrick M. M.

AU - Opmeer, Brent C.

AU - Mol, Ben Willem J.

AU - Schuit, Ewoud

AU - Van Baaren, Gert-Jan

PY - 2015/7

Y1 - 2015/7

N2 - ObjectiveTo stratify the risk of spontaneous preterm delivery using cervical length (CL) and fetal fibronectin (fFN) in women with threatened preterm labor who remained pregnant after 7days.DesignProspective observational study.SettingNationwide cohort of women with threatened preterm labor from the Netherlands.PopulationWomen with threatened preterm labor between 24 and 34weeks with a valid CL and fFN measurement and remaining pregnant 7days after admission.MethodsKaplan-Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR) for spontaneous delivery.Main outcome measuresSpontaneous delivery between 7 and 14days after initial presentation and spontaneous preterm delivery before 34weeks.ResultsThe risk of delivery between 7 and 14days was significantly increased for women with a CLConclusionsIn women remaining pregnant 7days after threatened preterm labor, CL and fFN results can be used in risk stratification for spontaneous delivery.

AB - ObjectiveTo stratify the risk of spontaneous preterm delivery using cervical length (CL) and fetal fibronectin (fFN) in women with threatened preterm labor who remained pregnant after 7days.DesignProspective observational study.SettingNationwide cohort of women with threatened preterm labor from the Netherlands.PopulationWomen with threatened preterm labor between 24 and 34weeks with a valid CL and fFN measurement and remaining pregnant 7days after admission.MethodsKaplan-Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR) for spontaneous delivery.Main outcome measuresSpontaneous delivery between 7 and 14days after initial presentation and spontaneous preterm delivery before 34weeks.ResultsThe risk of delivery between 7 and 14days was significantly increased for women with a CLConclusionsIn women remaining pregnant 7days after threatened preterm labor, CL and fFN results can be used in risk stratification for spontaneous delivery.

KW - Threatened preterm labor

KW - fetal fibronectin

KW - cervical length

KW - pregnancy complications

KW - risk

KW - prediction

KW - spontaneous preterm delivery

KW - ANTENATAL CORTICOSTEROIDS

KW - UTERINE CONTRACTIONS

KW - BIRTH

KW - PHARMACOKINETICS

KW - PREDICTOR

KW - TOCOLYSIS

KW - ACCURACY

KW - OUTCOMES

KW - COHORT

U2 - 10.1111/aogs.12643

DO - 10.1111/aogs.12643

M3 - Article

SN - 0001-6349

VL - 94

SP - 715

EP - 721

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 7

ER -

Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days

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