RNA interference in organ transplantation: Next-generation medicine?

Isabel M.A. Brüggenwirth, Paulo N. Martins

    OnderzoeksoutputAcademicpeer review


    Ischemia-reperfusion injury (IRI) is a major factor in graft quality and organ function after transplantation. Gene silencing through RNA interference (RNAi) may be used to suppress genes related to IRI and modify a graft before transplantation. RNAi is a natural process of posttranscriptional gene regulation that gained a lot of attention after winning the Nobel Prize in Medicine in 2006. Hence, several strategies have been used to deliver siRNA, and pretransplant machine perfusion presents a unique opportunity to deliver siRNA to the target organ during ex situ preservation. This book chapter discusses RNAi in the field of organ transplantation and considers whether this technique may be used as next-generation medicine. It gives a brief overview of the discovery of RNAi and its mechanism of action. In addition, studies using RNAi to target genes related to IRI in liver, kidney, lung, and heart transplantation are discussed.

    Originele taal-2English
    TitelOrgan Repair and Regeneration
    SubtitelPreserving Organs in the Regenerative Medicine Era
    RedacteurenGiuseppe Orlando, Shaf Keshavjee
    Aantal pagina's24
    ISBN van elektronische versie9780128194515
    StatusPublished - 29-jan.-2021

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