RNA Post-Transcriptional Modification Mapping Data Analysis Using RNA Framework

Ilaria Manfredonia, Danny Incarnato*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

1 Citaat (Scopus)


RNA post-transcriptional modifications (PTMs) are progressively gaining relevance in the study of coding-independent functions of RNA. RNA PTMs act as dynamic regulators of several aspects of the RNA physiology, from translation to half-life. Rising interest is supported by the advance of high-throughput techniques enabling the detection of these modifications on a transcriptome-wide scale. To this end, here we illustrate the usefulness of RNA Framework, a comprehensive toolkit for the analysis of RNA PTM mapping experiments, by reanalyzing two published transcriptome-scale datasets of N1-methyladenosine (m1A) and pseudouridine (Ψ) mapping, based on two different experimental strategies.

Originele taal-2English
TitelRNA Modifications. Methods in Molecular Biology
Redacteuren M. McMahon
Aantal pagina's11
StatusPublished - 4-jun-2021

Publicatie series

NaamMethods in Molecular Biology
ISSN van geprinte versie1064-3745

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