Role of the leptin signaling system in energy homeostasis

AB Steffens*, T Adage, K De Vries, R Adan, A Scheurink, G Van Dijk

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

Samenvatting

A regulated factor that contributes to maintenance of energy homeostasis is body weight and especially the size of its fat mass. Leptin as well as insulin are synthesized and secreted in proportion to body fat and each form a unique link between energy availability and CNS mechanisms that subserve the regulation of energy homeostasis. Both insulin and leptin affect signaling systems in the hypothalamus that involve a number of neuropeptides that serve a role in the regulation of food intake and energy expenditure. This chapter pays attention to to the interactions of leptin and insulin with hypopthalamic neuronal circuitry that contains neuropeptide Y (NPY), agouti-related peptide (AgRP) and proopiomelanocortin (POMC), and how these interactions affect appropriate changes in food intake and energy expenditure.

Originele taal-2English
TitelPERSPECTIVE IN COMPARATIVE ENDOCRINOLOGY: UNITY AND DIVERSITY
RedacteurenH. Vaudry, H.J.Th. Goos, R.K. Rastogi, R. Pierantoni
Plaats van productie40128 BOLOGNA
UitgeverijMEDIMOND PUBLISHING CO
Pagina's693-701
Aantal pagina's9
ISBN van geprinte versie88-323-1526-2
StatusPublished - 2001
Evenement14th International Congress of Comparative Endocrinology - , Italy
Duur: 26-mei-200130-mei-2001

Other

Other14th International Congress of Comparative Endocrinology
Land/RegioItaly
Periode26/05/200130/05/2001

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