Ruthenium and Iron-Catalysed Decarboxylative N-alkylation of Cyclic α-Amino Acids with Alcohols: Sustainable Routes to Pyrrolidine and Piperidine Derivatives

Anastasiia Afanasenko, Rachael Hannah, Tao Yan, Saravanakumar Elangovan, Katalin Barta*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: ArticleAcademicpeer review

15 Citaten (Scopus)
142 Downloads (Pure)


A modular and waste-free strategy for constructing N-substituted cyclic amines via decarboxylative N-alkylation of α-amino acids employing ruthenium- and iron-based catalysts is presented. The reported method allows the synthesis of a wide range of five- and six-membered N-alkylated heterocycles in moderate-to-excellent yields starting from predominantly proline and a broad range of benzyl alcohols, and primary and secondary aliphatic alcohols. Examples using pipecolic acid for the construction of piperidine derivatives, as well as the one-pot synthesis of α-amino nitriles, are also shown.

Originele taal-2English
Pagina's (van-tot)3801-3807
Aantal pagina's7
Nummer van het tijdschrift16
Vroegere onlinedatum22-jul.-2019
StatusPublished - 22-aug.-2019

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